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Treatment of subchondral cystic lesions (SCLs) with parathyroid hormone peptide (PTH1-34)-enriched fibrin hydrogel in three different concentrations: a dose-blinded, randomised study


Jackson, Michelle Amanda; Ohlerth, Stefanie; Brink, P; Simon, O; Kummer, Martin R; Fürst, Anton (2018). Treatment of subchondral cystic lesions (SCLs) with parathyroid hormone peptide (PTH1-34)-enriched fibrin hydrogel in three different concentrations: a dose-blinded, randomised study. Equine Veterinary Education:Epub ahead of print-...

Abstract

This study reports the use of parathyroid hormone fragment peptide 1‐34 (PTH1‐34) cross‐linked to a hydrogel in a fibrin base for the treatment of subchondral cyst‐like lesions (SCLs). The objectives were to determine the clinical and radiographic outcome of 28 horses with lameness attributable to one or two SCLs treated locally with one of three different concentrations of PTH1‐34 and to identify which concentration produces the best results. Twenty‐eight horses (34 SCLs) were treated surgically by debriding the content of the SCL and injecting different concentrations (0.1, 0.4, or 1 mg/mL) of PTH1‐34 in a fibrin hydrogel into the cavity. Treatment was considered successful if the horse was sound 12 months after treatment. The mean age of the horses was 7.2 years. Treatment was successful in 22 (78.6%) horses and improved the radiographic appearance of 27 (79.4%) SCLs. The outcome was not affected by age of the horse or by the number of SCLs (1 or 2) per horse. PTH1‐34 in a fibrin hydrogel administered into the SCL after surgical debridement of the lesion appears to be an effective treatment for horses with one or two SCLs. A PTH1‐34 concentration of 0.4 mg/mL may be slightly superior to concentrations of 0.1 and 1.0 mg/mL in resolving SCLs.

Abstract

This study reports the use of parathyroid hormone fragment peptide 1‐34 (PTH1‐34) cross‐linked to a hydrogel in a fibrin base for the treatment of subchondral cyst‐like lesions (SCLs). The objectives were to determine the clinical and radiographic outcome of 28 horses with lameness attributable to one or two SCLs treated locally with one of three different concentrations of PTH1‐34 and to identify which concentration produces the best results. Twenty‐eight horses (34 SCLs) were treated surgically by debriding the content of the SCL and injecting different concentrations (0.1, 0.4, or 1 mg/mL) of PTH1‐34 in a fibrin hydrogel into the cavity. Treatment was considered successful if the horse was sound 12 months after treatment. The mean age of the horses was 7.2 years. Treatment was successful in 22 (78.6%) horses and improved the radiographic appearance of 27 (79.4%) SCLs. The outcome was not affected by age of the horse or by the number of SCLs (1 or 2) per horse. PTH1‐34 in a fibrin hydrogel administered into the SCL after surgical debridement of the lesion appears to be an effective treatment for horses with one or two SCLs. A PTH1‐34 concentration of 0.4 mg/mL may be slightly superior to concentrations of 0.1 and 1.0 mg/mL in resolving SCLs.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Veterinary Clinic > Equine Department
05 Vetsuisse Faculty > Veterinary Clinic > Department of Clinical Diagnostics and Services
Dewey Decimal Classification:570 Life sciences; biology
630 Agriculture
Uncontrolled Keywords:Equine
Language:English
Date:21 November 2018
Deposited On:27 Nov 2018 10:14
Last Modified:28 Feb 2019 08:22
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:0957-7734
OA Status:Closed
Publisher DOI:https://doi.org/10.1111/eve.13022

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