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Lower exhaled nitric oxide in infants with Cystic Fibrosis compared to healthy controls


Korten, Insa; Liechti, Margot; Singer, Florian; Hafen, Gaudenz; Rochat, Isabelle; Anagnostopoulou, Pinelopi; Müller-Suter, Dominik; Usemann, Jakob; Moeller, Alexander; Frey, Urs; Latzin, Philipp; Casaulta, Carmen; SCILD study group; BILD study group (2018). Lower exhaled nitric oxide in infants with Cystic Fibrosis compared to healthy controls. Journal of Cystic Fibrosis, 17(1):105-108.

Abstract

Exhaled nitric oxide (FE) is a well-known, non-invasive airway biomarker. In patients with Cystic Fibrosis (CF) FE is decreased. To understand if reduced FE is primary related to Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) dysfunction or an epiphenomenon of chronic inflammation, we measured FE in 34 infants with CF prior to clinical symptoms and in 68 healthy controls. FE was lower in CF compared to controls (p=0.0006) and the effect was more pronounced in CF infants without residual CFTR function (p<0.0001). This suggests that FE is reduced in CF early in life, possibly associated with underlying CFTR dysfunction.

Abstract

Exhaled nitric oxide (FE) is a well-known, non-invasive airway biomarker. In patients with Cystic Fibrosis (CF) FE is decreased. To understand if reduced FE is primary related to Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) dysfunction or an epiphenomenon of chronic inflammation, we measured FE in 34 infants with CF prior to clinical symptoms and in 68 healthy controls. FE was lower in CF compared to controls (p=0.0006) and the effect was more pronounced in CF infants without residual CFTR function (p<0.0001). This suggests that FE is reduced in CF early in life, possibly associated with underlying CFTR dysfunction.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:January 2018
Deposited On:07 Dec 2018 09:08
Last Modified:08 Dec 2018 08:33
Publisher:Elsevier
ISSN:1569-1993
OA Status:Closed
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1016/j.jcf.2017.05.005
PubMed ID:28716479

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