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A histidine-rich Pseudomonas metallothionein with a disordered tail displays higher binding capacity for cadmium than zinc


Habjanič, Jelena; Zerbe, Oliver; Freisinger, Eva (2018). A histidine-rich Pseudomonas metallothionein with a disordered tail displays higher binding capacity for cadmium than zinc. Metallomics, 10(10):1415-1429.

Abstract

The NMR solution structure of a <italic>Pseudomonas</italic> metallothionein reveals a different binding capacity for Zn<sup>II</sup> and Cd<sup>II</sup> ions that results in two novel metal-cluster topologies. Replacement of a non-coordinating residue by histidine decreases the kinetic lability of the cluster. All three structures reported show an identical protein fold.

Abstract

The NMR solution structure of a <italic>Pseudomonas</italic> metallothionein reveals a different binding capacity for Zn<sup>II</sup> and Cd<sup>II</sup> ions that results in two novel metal-cluster topologies. Replacement of a non-coordinating residue by histidine decreases the kinetic lability of the cluster. All three structures reported show an identical protein fold.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Language:English
Date:1 January 2018
Deposited On:07 Dec 2018 10:30
Last Modified:08 Dec 2018 08:33
Publisher:Royal Society of Chemistry
ISSN:1756-5901
OA Status:Closed
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1039/c8mt00193f

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