Header

UZH-Logo

Maintenance Infos

Transgenerational Epigenetics of Traumatic Stress


Jawaid, Ali; Roszkowski, Martin; Mansuy, Isabelle M (2018). Transgenerational Epigenetics of Traumatic Stress. In: Rutten, Bart P F. Neuroepigenetics and Mental Illness. Amsterdam: Elsevier, 273-298.

Abstract

Traumatic stress is a type of environmental experience that can modify behavior, cognition and physiological functions such as metabolism, in mammals. Many of the effects of traumatic stress can be transmitted to subsequent generations even when individuals from these generations are not exposed to any traumatic stressor. This book chapter discusses the concept of epigenetic/non-genomic inheritance of such traits involving the germline in mammals. It includes a comprehensive review of animal and human studies on inter- and transgenerational inheritance of the effects of traumatic stress, some of the epigenetic changes in the germline currently known to be associated with traumatic stress, and possible mechanisms for their induction and maintenance during development and adulthood. We also describe some experimental interventions that attempted to prevent the transmission of these effects, and consider the evolutionary importance of transgenerational inheritance and future outlook of the field.

Abstract

Traumatic stress is a type of environmental experience that can modify behavior, cognition and physiological functions such as metabolism, in mammals. Many of the effects of traumatic stress can be transmitted to subsequent generations even when individuals from these generations are not exposed to any traumatic stressor. This book chapter discusses the concept of epigenetic/non-genomic inheritance of such traits involving the germline in mammals. It includes a comprehensive review of animal and human studies on inter- and transgenerational inheritance of the effects of traumatic stress, some of the epigenetic changes in the germline currently known to be associated with traumatic stress, and possible mechanisms for their induction and maintenance during development and adulthood. We also describe some experimental interventions that attempted to prevent the transmission of these effects, and consider the evolutionary importance of transgenerational inheritance and future outlook of the field.

Statistics

Citations

Dimensions.ai Metrics
3 citations in Web of Science®
1 citation in Scopus®
Google Scholar™

Altmetrics

Additional indexing

Item Type:Book Section, refereed, original work
Communities & Collections:04 Faculty of Medicine > Brain Research Institute
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Uncontrolled Keywords:Epigenetics; Germ line; Human; Intergenerational; Rodent; Stress; Transgenerational; Trauma
Language:English
Date:1 January 2018
Deposited On:03 Jan 2019 09:01
Last Modified:03 Jan 2019 09:12
Publisher:Elsevier
Series Name:Progress in molecular biology and translational science
Number:158
ISSN:1877-1173
ISBN:9780128125922
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/bs.pmbts.2018.03.003
Related URLs:https://www.recherche-portal.ch/primo-explore/fulldisplay?docid=ebi01_prod005743319&context=L&vid=ZAD&search_scope=default_scope&tab=default_tab&lang=de_DE (Library Catalogue)
PubMed ID:30072057

Download

Full text not available from this repository.
View at publisher

Get full-text in a library