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Comparison of DTI analysis methods for clinical research: influence of pre-processing and tract selection methods


Ressel, Volker; van Hedel, Hubertus J A; Scheer, Ianina; O'Gorman Tuura, Ruth (2018). Comparison of DTI analysis methods for clinical research: influence of pre-processing and tract selection methods. European Radiology Experimental, 2:33.

Abstract

BACKGROUND The primary aim was to compare fractional anisotropy (FA) values derived with different diffusion tensor imaging (DTI) analysis approaches (atlas-based, streamline tractography, and combined). A secondary aim was to compare FA values and number of tracts (NT) with the clinical motor outcome quantified by the functional independence measure for children (WeeFIM).
METHODS Thirty-nine DTI datasets of children with acquired brain injury were analysed. Regions of interest for the ipsilesional corticospinal tract were defined and mean FA and NT were calculated. We evaluated FA values with Spearman correlation, the Friedman and Wilcoxon tests, and Bland-Altman analysis. DTI values were compared to WeeFIM values by non-parametric partial correlation and accuracy was assessed by receiver operating characteristics analysis.
RESULTS The FA values from all approaches correlated significantly with each other (p < 0.001). However, the FA values from streamline tractography were significantly higher (mean ± standard deviation (SD), 0.52 ± 0.08) than those from the atlas-based (0.42 ± 0.11) or the combined approach (0.41 ± 0.11) (p < 0.001 for both). FA and NT values correlated significantly with WeeFIM values (atlas-based FA, partial correlation coefficient (ρ) = 0.545, p = 0.001; streamline FA, ρ = 0.505, p = 0.002; NT, ρ = 0.434, p = 0.008; combined FA, ρ = 0.611, p < 0.001). FA of the atlas-based approach (sensitivity 90%, specificity 67%, area under the curve 0.82) and the combined approach (87%, 67%, 0.82), provided the highest predictive accuracy for outcome compared to FA (70%, 67%, 0.67) and NT (50%, 100%, 0.79, respectively) of the streamline approach.
CONCLUSION FA values from streamline tractography were higher than those from the atlas-based and combined approach. The atlas-based and combined approach offer the best predictive accuracy for motor outcome, although both atlas-based and streamline tractography approaches provide significant predictors of clinical outcome.

Abstract

BACKGROUND The primary aim was to compare fractional anisotropy (FA) values derived with different diffusion tensor imaging (DTI) analysis approaches (atlas-based, streamline tractography, and combined). A secondary aim was to compare FA values and number of tracts (NT) with the clinical motor outcome quantified by the functional independence measure for children (WeeFIM).
METHODS Thirty-nine DTI datasets of children with acquired brain injury were analysed. Regions of interest for the ipsilesional corticospinal tract were defined and mean FA and NT were calculated. We evaluated FA values with Spearman correlation, the Friedman and Wilcoxon tests, and Bland-Altman analysis. DTI values were compared to WeeFIM values by non-parametric partial correlation and accuracy was assessed by receiver operating characteristics analysis.
RESULTS The FA values from all approaches correlated significantly with each other (p < 0.001). However, the FA values from streamline tractography were significantly higher (mean ± standard deviation (SD), 0.52 ± 0.08) than those from the atlas-based (0.42 ± 0.11) or the combined approach (0.41 ± 0.11) (p < 0.001 for both). FA and NT values correlated significantly with WeeFIM values (atlas-based FA, partial correlation coefficient (ρ) = 0.545, p = 0.001; streamline FA, ρ = 0.505, p = 0.002; NT, ρ = 0.434, p = 0.008; combined FA, ρ = 0.611, p < 0.001). FA of the atlas-based approach (sensitivity 90%, specificity 67%, area under the curve 0.82) and the combined approach (87%, 67%, 0.82), provided the highest predictive accuracy for outcome compared to FA (70%, 67%, 0.67) and NT (50%, 100%, 0.79, respectively) of the streamline approach.
CONCLUSION FA values from streamline tractography were higher than those from the atlas-based and combined approach. The atlas-based and combined approach offer the best predictive accuracy for motor outcome, although both atlas-based and streamline tractography approaches provide significant predictors of clinical outcome.

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Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Radiology, Nuclear Medicine and Imaging
Language:English
Date:14 November 2018
Deposited On:09 Jan 2019 16:49
Last Modified:11 May 2020 18:19
Publisher:SpringerOpen
ISSN:2509-9280
OA Status:Gold
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1186/s41747-018-0066-1
PubMed ID:30426317

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