We discuss the renormalization of mixing angles for theories with extended scalar sectors. Motivated by shortcomings of existing schemes for mixing angles, we review existing renormalization schemes and introduce new ones based on on-shell conditions or symmetry requirements such as rigid or background-field gauge invariance. Considering in particular the renormalization of the mixing angles in the Two-Higgs-Doublet Model and the Higgs-Singlet Extension of the Standard Model, we compare electroweak corrections within these models for a selection of renormalization schemes. As specific examples, we present next-to-leading-order results on the four-fermion decays of heavy and light CP-even Higgs bosons, H1/H2 → WW/ZZ → 4f , and on electroweak Higgs-boson production processes, i.e. Higgs-strahlung and vector-boson fusion. We find that our new proposals for on-shell and symmetry-based renormalization conditions are well-behaved for the considered benchmark scenarios in both models.