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Inflammation: A Contributor to Depressive Comorbidity in Inflammatory Skin Disease


Farzanfar, Delaram; Dowlati, Yekta; French, Lars E; Lowes, Michelle A; Alavi, Afsaneh (2018). Inflammation: A Contributor to Depressive Comorbidity in Inflammatory Skin Disease. Skin Pharmacology and Physiology, 31(5):246-251.

Abstract

The prevalence of affective disorders such as depression and anxiety is particularly high in patients with autoimmune diseases, including inflammatory skin diseases such as psoriasis, atopic dermatitis, and hidradenitis suppurativa. A dysregulated immune response has been linked to the precipitation of depression in many patient populations. However, studies examining the extent to which the underlying skin disease inflammatory processes contribute to depression and a subsequent decline in quality of life are limited. The published literature over the past 5 years was reviewed for evidence of a relationship between depression and inflammatory processes in the context of skin pathology. The findings, particularly the evidence from interventional clinical trials of targeted anti-cytokine therapies, suggest that pro-inflammatory cytokines associated with several skin diseases may be causally linked with the coexistent depressive symptomology.

Abstract

The prevalence of affective disorders such as depression and anxiety is particularly high in patients with autoimmune diseases, including inflammatory skin diseases such as psoriasis, atopic dermatitis, and hidradenitis suppurativa. A dysregulated immune response has been linked to the precipitation of depression in many patient populations. However, studies examining the extent to which the underlying skin disease inflammatory processes contribute to depression and a subsequent decline in quality of life are limited. The published literature over the past 5 years was reviewed for evidence of a relationship between depression and inflammatory processes in the context of skin pathology. The findings, particularly the evidence from interventional clinical trials of targeted anti-cytokine therapies, suggest that pro-inflammatory cytokines associated with several skin diseases may be causally linked with the coexistent depressive symptomology.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Dermatology Clinic
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:Physiology, Pharmacology, Dermatology, General Medicine, Atopic dermatitis, Depression, Hidradenitis suppurativa, Inflammation, Psoriasis, Skin disorders
Language:English
Date:1 January 2018
Deposited On:04 Jan 2019 10:59
Last Modified:25 Sep 2019 00:01
Publisher:Karger
ISSN:1660-5527
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.1159/000490002
PubMed ID:29953999

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