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Osteogenic efficacy of BMP-2 mixed with hydrogel and bone substitute in peri-implant dehiscence defects in dogs: 16 weeks of healing


Cha, Jae-Kook; Jung, Ui-Won; Thoma, Daniel S; Hämmerle, Christoph H F; Jung, Ronald E (2018). Osteogenic efficacy of BMP-2 mixed with hydrogel and bone substitute in peri-implant dehiscence defects in dogs: 16 weeks of healing. Clinical Oral Implants Research, 29(3):300-308.

Abstract

Objectives The objective of this study was to determine the effect of bone morphogenetic protein‐2 (BMP‐2) mixed with either polyethylene glycol hydrogel or synthetic bone substitute (SBS) on new bone formation in peri‐implant dehiscence defects after 16 weeks of healing. Materials and methods A guided bone regeneration procedure was performed in box‐type peri‐implant defects that were surgically prepared in six beagle dogs. The following four experimental groups were used (i) control (no graft), (ii) SBS+hydrogel, (iii) SBS+BMP‐2/hydrogel and (iv) BMP‐2/SBS+hydrogel. Volumetric analysis using micro‐computed tomography and histomorphometric analysis was performed at 16 weeks post‐operatively. Results The amount of new bone and the total augmented volume did not differ significantly between both BMP‐treated groups and the SBS+hydrogel group (p > .05). Likewise, no histometric differences were observed in the values of new bone area and bone‐to‐implant contact ratio among the three augmentation groups (new bone area: 0.06 ± 0.08, 0.19 ± 0.20, 0.48 ± 0.37 and 0.56 ± 0.60 mm2 [mean ± standard deviation] in groups 1–4, respectively; bone‐to‐implant contact: 9.44 ± 11.51%, 19.91 ± 15.19%, 46.31 ± 29.82% and 42.58 ± 26.27% in groups 1–4, respectively). Conclusion The osteogenic efficacy of BMP‐2 on the regeneration of peri‐implant bone defects was not detectable after 16 weeks regardless of the carrier materials.

Abstract

Objectives The objective of this study was to determine the effect of bone morphogenetic protein‐2 (BMP‐2) mixed with either polyethylene glycol hydrogel or synthetic bone substitute (SBS) on new bone formation in peri‐implant dehiscence defects after 16 weeks of healing. Materials and methods A guided bone regeneration procedure was performed in box‐type peri‐implant defects that were surgically prepared in six beagle dogs. The following four experimental groups were used (i) control (no graft), (ii) SBS+hydrogel, (iii) SBS+BMP‐2/hydrogel and (iv) BMP‐2/SBS+hydrogel. Volumetric analysis using micro‐computed tomography and histomorphometric analysis was performed at 16 weeks post‐operatively. Results The amount of new bone and the total augmented volume did not differ significantly between both BMP‐treated groups and the SBS+hydrogel group (p > .05). Likewise, no histometric differences were observed in the values of new bone area and bone‐to‐implant contact ratio among the three augmentation groups (new bone area: 0.06 ± 0.08, 0.19 ± 0.20, 0.48 ± 0.37 and 0.56 ± 0.60 mm2 [mean ± standard deviation] in groups 1–4, respectively; bone‐to‐implant contact: 9.44 ± 11.51%, 19.91 ± 15.19%, 46.31 ± 29.82% and 42.58 ± 26.27% in groups 1–4, respectively). Conclusion The osteogenic efficacy of BMP‐2 on the regeneration of peri‐implant bone defects was not detectable after 16 weeks regardless of the carrier materials.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Center for Dental Medicine > Clinic for Fixed and Removable Prosthodontics
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:1 March 2018
Deposited On:23 Jan 2019 14:49
Last Modified:24 Jan 2019 08:37
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:0905-7161
OA Status:Closed
Publisher DOI:https://doi.org/10.1111/clr.13117
PubMed ID:29341335

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