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Acute effects of hypertonic saline inhalation on nitric oxide pulmonary diffusing capacity in healthy adults


Karrasch, S; Radtke, Thomas; Simon, M; Kronseder, A; Dressel, Holger; Jörres, R A; Ochmann, U (2018). Acute effects of hypertonic saline inhalation on nitric oxide pulmonary diffusing capacity in healthy adults. Respiratory Physiology & Neurobiology, 258:40-46.

Abstract

We investigated acute effects of inhalation of hypertonic saline solution (HSS) and oxygen (O2, control exposure) on pulmonary diffusing capacity for nitric oxide (DLNO) and carbon monoxide (DLCO). In a randomized crossover study, 20 healthy, non-smoking subjects were allocated to short-term inhalation of HSS or O2. Spirometry [(forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC)] and combined single-breath DLNO-DLCO measurements were performed before and immediately after inhalation of either HSS or O2. Percent changes were presented as median values (interquartile range). After HSS inhalation, DLNO, FEV1 and FVC were decreased by −3.0% (−7.3, 0.5), −3.1% (−4.2, −1.6) and −1.2% (−3.3, 0.6), respectively (all P < 0.05), without significant effect on DLCO. No changes in spirometry and diffusing capacity were observed following O2 inhalation. Acute inhalation of HSS causes a slight decrease in membrane conductance, probably as a result of fluid imbalance at the alveolar surface and interstitial fluid accumulation, both of which could impair gas exchange.

Abstract

We investigated acute effects of inhalation of hypertonic saline solution (HSS) and oxygen (O2, control exposure) on pulmonary diffusing capacity for nitric oxide (DLNO) and carbon monoxide (DLCO). In a randomized crossover study, 20 healthy, non-smoking subjects were allocated to short-term inhalation of HSS or O2. Spirometry [(forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC)] and combined single-breath DLNO-DLCO measurements were performed before and immediately after inhalation of either HSS or O2. Percent changes were presented as median values (interquartile range). After HSS inhalation, DLNO, FEV1 and FVC were decreased by −3.0% (−7.3, 0.5), −3.1% (−4.2, −1.6) and −1.2% (−3.3, 0.6), respectively (all P < 0.05), without significant effect on DLCO. No changes in spirometry and diffusing capacity were observed following O2 inhalation. Acute inhalation of HSS causes a slight decrease in membrane conductance, probably as a result of fluid imbalance at the alveolar surface and interstitial fluid accumulation, both of which could impair gas exchange.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Epidemiology, Biostatistics and Prevention Institute (EBPI)
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:Physiology, General Neuroscience, Pulmonary and Respiratory Medicine
Language:English
Date:1 December 2018
Deposited On:31 Jan 2019 12:20
Last Modified:17 Sep 2019 19:53
Publisher:Elsevier
ISSN:1569-9048
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.resp.2018.09.007

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