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Characterization of the optical properties of color pastes for the design of optical phantoms mimicking biological tissue


Tomm, Natasha; Ahnen, Linda; Isler, Helene; Kleiser, Stefan; Karen, Tanja; Ostojic, Daniel; Wolf, Martin; Scholkmann, Felix (2019). Characterization of the optical properties of color pastes for the design of optical phantoms mimicking biological tissue. Journal of Biophotonics, 12(4):e201800300.

Abstract

Clinicians need a way to rapidly and reliably test the correct functioning of near-infrared spectroscopy (NIRS)-based oximeters. Therefore, optical phantoms for quality assessment of NIRS oximeters are needed. The fabrication of such phantoms that mimic the optical properties of biological tissue in the NIR range represents a challenge. To enable their development, the aim was to characterize the absorption and scattering spectra of different dyes. The optical properties of silicone SILPURAN 2420 with 11 color pastes of type ELASTOSIL were measured in the 500 to 1000 nm range by a spectrometer with an integrating sphere. In addition, two commercial frequency-domain NIRS devices, the ISS OxiplexTS and the ISS Imagent, were used to assess the optical properties at specific wavelengths. The evaluated colors present mostly features in the visible range below 650 nm, but two colors include peaks in the near-infrared region, simulating low tissue oxygenation values. These colors were used to create an optical phantom, which matched the designed StO value within an error of only 4%. This set of dyes already enables simulating many different spectra, thus achieving a first step on the way to a long-term stable comparison and validation method.

Abstract

Clinicians need a way to rapidly and reliably test the correct functioning of near-infrared spectroscopy (NIRS)-based oximeters. Therefore, optical phantoms for quality assessment of NIRS oximeters are needed. The fabrication of such phantoms that mimic the optical properties of biological tissue in the NIR range represents a challenge. To enable their development, the aim was to characterize the absorption and scattering spectra of different dyes. The optical properties of silicone SILPURAN 2420 with 11 color pastes of type ELASTOSIL were measured in the 500 to 1000 nm range by a spectrometer with an integrating sphere. In addition, two commercial frequency-domain NIRS devices, the ISS OxiplexTS and the ISS Imagent, were used to assess the optical properties at specific wavelengths. The evaluated colors present mostly features in the visible range below 650 nm, but two colors include peaks in the near-infrared region, simulating low tissue oxygenation values. These colors were used to create an optical phantom, which matched the designed StO value within an error of only 4%. This set of dyes already enables simulating many different spectra, thus achieving a first step on the way to a long-term stable comparison and validation method.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neonatology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:1 April 2019
Deposited On:05 Feb 2019 15:29
Last Modified:25 Sep 2019 00:05
Publisher:Wiley-VCH Verlag
ISSN:1864-063X
OA Status:Closed
Publisher DOI:https://doi.org/10.1002/jbio.201800300
PubMed ID:30379410

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