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Source and microenvironmental regulation of erythropoietin in the kidney


Nolan, Karen A; Wenger, R H (2018). Source and microenvironmental regulation of erythropoietin in the kidney. Current Opinion in Nephrology and Hypertension, 27:277-282.

Abstract

We hypothesize that REP cells are neuron-like setpoint providers and controllers, which integrate information about blood O2 concentration and local O2 consumption via tissue pO2, and combine these inputs with intrinsic negative feedback loops and perhaps tubular cross-talk, converging in Epo regulation.

Abstract

We hypothesize that REP cells are neuron-like setpoint providers and controllers, which integrate information about blood O2 concentration and local O2 consumption via tissue pO2, and combine these inputs with intrinsic negative feedback loops and perhaps tubular cross-talk, converging in Epo regulation.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute of Physiology
07 Faculty of Science > Institute of Physiology
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Scopus Subject Areas:Health Sciences > Internal Medicine
Health Sciences > Nephrology
Language:English
Date:2018
Deposited On:12 Feb 2019 16:59
Last Modified:26 Jan 2022 20:03
Publisher:Lippincott Williams & Wilkins
ISSN:1062-4821
OA Status:Green
Publisher DOI:https://doi.org/10.1097/MNH.0000000000000420
Project Information:
  • : Funderwiss National Science Foundation (NCCR ‘Kidney.CH’ and grant Nr 165679
  • : Grant ID165679
  • : Project Title
  • : FunderFP7
  • : Grant ID608847
  • : Project TitleInternational Fellowship Program on Integrative Kidney Physiology and Pathophysiology
  • Content: Published Version