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The Toll pathway inhibits tissue growth and regulates cell fitness in an infection-dependent manner


Germani, Federico; Hain, Daniel; Sternlicht, Denise; Moreno, Eduardo; Basler, Konrad (2018). The Toll pathway inhibits tissue growth and regulates cell fitness in an infection-dependent manner. eLife, 7:e39939.

Abstract

The Toll pathway regulates the cellular response to infection via the transcriptional upregulation of antimicrobial peptides. In , apart from its role in innate immunity, this pathway has also been reported to be important for the elimination of loser cells in a process referred to as cell competition, which can be locally triggered by secreted factors released from winner cells. In this work, we provide evidence that the inhibition of Toll signaling not only increases the fitness of loser cells, but also bestows a clonal growth advantage on wild-type cells. We further demonstrate that this growth advantage depends on basal infection levels since it is no longer present under axenic conditions but exacerbated upon intense pathogen exposure. Thus, the Toll pathway functions as a fine-tuned pro-apoptotic and anti-proliferative regulator, underlining the existence of a trade-off between innate immunity and growth during development.

Abstract

The Toll pathway regulates the cellular response to infection via the transcriptional upregulation of antimicrobial peptides. In , apart from its role in innate immunity, this pathway has also been reported to be important for the elimination of loser cells in a process referred to as cell competition, which can be locally triggered by secreted factors released from winner cells. In this work, we provide evidence that the inhibition of Toll signaling not only increases the fitness of loser cells, but also bestows a clonal growth advantage on wild-type cells. We further demonstrate that this growth advantage depends on basal infection levels since it is no longer present under axenic conditions but exacerbated upon intense pathogen exposure. Thus, the Toll pathway functions as a fine-tuned pro-apoptotic and anti-proliferative regulator, underlining the existence of a trade-off between innate immunity and growth during development.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:19 November 2018
Deposited On:15 Feb 2019 16:18
Last Modified:15 Feb 2019 16:18
Publisher:eLife Sciences Publications Ltd.
ISSN:2050-084X
OA Status:Gold
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.7554/eLife.39939
PubMed ID:30451683

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