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Short Communication: Management of patients with extensive-stage small-cell lung cancer treated with radiotherapy: A survey of practice


Haslett, Kate; De Ruysscher, Dirk; Dziadziuszko, Rafal; Guckenberger, Matthias; Pechoux, Cecile Le; Nestle, Ursula; Slotman, Ben; Faivre-Finn, Corinne (2018). Short Communication: Management of patients with extensive-stage small-cell lung cancer treated with radiotherapy: A survey of practice. Cancer Treatment and Research Communications, 17:18-22.

Abstract

OBJECTIVES
The results of the randomized phase 3 CREST trial evaluating the use of thoracic radiotherapy for extensive-stage small-cell lung cancer (ES-SCLC) were published in the Lancet in 2015. The primary endpoint (10% overall survival difference at 1-year) was not achieved, but there was significant improvement in 2-year overall survival (13% vs 3%; p = 0.004) and low toxicity rates, suggesting thoracic radiotherapy should be considered for ES-SCLC patients who respond to chemotherapy. Questions have been raised as to whether these results will lead to a change in practice.

MATERIALS AND METHODS
We developed an electronic survey to determine the impact of the publication on clinical practice across some European countries.

RESULTS AND CONCLUSION
We report the results of our survey, which suggest the CREST trial has changed practice, resulting in an increase in the use of thoracic radiotherapy amongst the surveyed centers from 25% to 85%. Furthermore the dose and fractionation schedule used in the trial has been widely adopted across Europe.

Abstract

OBJECTIVES
The results of the randomized phase 3 CREST trial evaluating the use of thoracic radiotherapy for extensive-stage small-cell lung cancer (ES-SCLC) were published in the Lancet in 2015. The primary endpoint (10% overall survival difference at 1-year) was not achieved, but there was significant improvement in 2-year overall survival (13% vs 3%; p = 0.004) and low toxicity rates, suggesting thoracic radiotherapy should be considered for ES-SCLC patients who respond to chemotherapy. Questions have been raised as to whether these results will lead to a change in practice.

MATERIALS AND METHODS
We developed an electronic survey to determine the impact of the publication on clinical practice across some European countries.

RESULTS AND CONCLUSION
We report the results of our survey, which suggest the CREST trial has changed practice, resulting in an increase in the use of thoracic radiotherapy amongst the surveyed centers from 25% to 85%. Furthermore the dose and fractionation schedule used in the trial has been widely adopted across Europe.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Radiation Oncology
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Oncology
Life Sciences > Cancer Research
Language:English
Date:2018
Deposited On:25 Jan 2019 11:59
Last Modified:12 Sep 2020 10:51
Publisher:Elsevier
ISSN:2468-2942
OA Status:Hybrid
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1016/j.ctarc.2018.08.004
PubMed ID:30196134

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