Header

UZH-Logo

Maintenance Infos

Impact of gender on outcomes after transcatheter aortic valve implantation


Yousif, Nooraldaem; Obeid, Slayman; Binder, Ronald; Denegri, Andrea; Shahin, Mohammady; Templin, Christian; Lüscher, Thomas F (2018). Impact of gender on outcomes after transcatheter aortic valve implantation. Journal of Geriatric Cardiology, 15(6):394-400.

Abstract

Backgound The influence of gender on clinical outcomes following transcatheter aortic valve implantation (TAVI) was considerably discrepant in previous studies. We aimed to investigate the impact of gender in our registry.
Methods The study is a retrospective observational analysis of a prospectively designed cohort (546 consecutive patients treated at the University Hospital Zurich who were enrolled in Swiss TAVI Cohort from May 2008 to April 2014). The Study took place in University Heart Centre at University Hospital Zurich, Switzerland.
Results Both genders were equally represented with 51.5 % ( = 281) of the populations being females, who were significantly older and had a more pronounced history of hypertension ( < 0.001). Males on the other hand showed a higher incidence of diabetes ( = 0.004), coronary artery disease ( < 0.001), chronic obstructive pulmonary disease ( < 0.001) and renal failure requiring renal replacement therapy ( = 0.018). Patients were followed up for a median of 391 days with a 100% complete follow-up at one year. The primary outcome (all-cause mortality) occurred in 6.8% ( = 37) and 15% ( = 82) of patients at 30 days and one year, respectively. The 30-day all-cause mortality outcome did not significantly differ between females (7.5%) and males (6.0%) ( = 0.619), but one year all-cause mortality occurred significantly more in males than in females (18.7% . 11.7%, < 0.037).
Conclusion After TAVI implantation for severe aortic stenosis, males have a less favorable long-term (one year) mortality outcome than females.

Abstract

Backgound The influence of gender on clinical outcomes following transcatheter aortic valve implantation (TAVI) was considerably discrepant in previous studies. We aimed to investigate the impact of gender in our registry.
Methods The study is a retrospective observational analysis of a prospectively designed cohort (546 consecutive patients treated at the University Hospital Zurich who were enrolled in Swiss TAVI Cohort from May 2008 to April 2014). The Study took place in University Heart Centre at University Hospital Zurich, Switzerland.
Results Both genders were equally represented with 51.5 % ( = 281) of the populations being females, who were significantly older and had a more pronounced history of hypertension ( < 0.001). Males on the other hand showed a higher incidence of diabetes ( = 0.004), coronary artery disease ( < 0.001), chronic obstructive pulmonary disease ( < 0.001) and renal failure requiring renal replacement therapy ( = 0.018). Patients were followed up for a median of 391 days with a 100% complete follow-up at one year. The primary outcome (all-cause mortality) occurred in 6.8% ( = 37) and 15% ( = 82) of patients at 30 days and one year, respectively. The 30-day all-cause mortality outcome did not significantly differ between females (7.5%) and males (6.0%) ( = 0.619), but one year all-cause mortality occurred significantly more in males than in females (18.7% . 11.7%, < 0.037).
Conclusion After TAVI implantation for severe aortic stenosis, males have a less favorable long-term (one year) mortality outcome than females.

Statistics

Citations

Altmetrics

Downloads

1 download since deposited on 01 Mar 2019
1 download since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, not_refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Cardiology
04 Faculty of Medicine > Center for Molecular Cardiology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:June 2018
Deposited On:01 Mar 2019 10:46
Last Modified:13 Mar 2019 10:42
Publisher:Science Press
ISSN:1671-5411
OA Status:Green
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.11909/j.issn.1671-5411.2018.06.013
PubMed ID:30108610

Download

Download PDF  'Impact of gender on outcomes after transcatheter aortic valve implantation'.
Preview
Content: Published Version
Filetype: PDF
Size: 385kB
View at publisher