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Spectral correction for handheld optoacoustic imaging by means of near-infrared optical tomography in reflection mode


Ulrich, Leonie; Ahnen, Linda; Akarçay, Hidayet Günhan; Majos, Salvador Sánchez; Jaeger, Michael; Held, Kai Gerrit; Wolf, Martin; Frenz, Martin (2019). Spectral correction for handheld optoacoustic imaging by means of near-infrared optical tomography in reflection mode. Journal of Biophotonics, 12(1):e201800112.

Abstract

In vivo imaging of tissue/vasculature oxygen saturation levels is of prime interest in many clinical applications. To this end, the feasibility of combining two distinct and complementary imaging modalities is investigated: optoacoustics (OA) and near-infrared optical tomography (NIROT), both operating noninvasively in reflection mode. Experiments were conducted on two optically heterogeneous phantoms mimicking tissue before and after the occurrence of a perturbation. OA imaging was used to resolve submillimetric vessel-like optical absorbers at depths up to 25 mm, but with a spectral distortion in the OA signals. NIROT measurements were utilized to image perturbations in the background and to estimate the light fluence inside the phantoms at the wavelength pair (760 nm, 830 nm). This enabled the spectral correction of the vessel-like absorbers' OA signals: the error in the ratio of the absorption coefficient at 830 nm to that at 760 nm was reduced from 60%-150% to 10%-20%. The results suggest that oxygen saturation (SO ) levels in arteries can be determined with <10% error and furthermore, that relative changes in vessels' SO can be monitored with even better accuracy. The outcome relies on a proper identification of the OA signals emanating from the studied vessels.

Abstract

In vivo imaging of tissue/vasculature oxygen saturation levels is of prime interest in many clinical applications. To this end, the feasibility of combining two distinct and complementary imaging modalities is investigated: optoacoustics (OA) and near-infrared optical tomography (NIROT), both operating noninvasively in reflection mode. Experiments were conducted on two optically heterogeneous phantoms mimicking tissue before and after the occurrence of a perturbation. OA imaging was used to resolve submillimetric vessel-like optical absorbers at depths up to 25 mm, but with a spectral distortion in the OA signals. NIROT measurements were utilized to image perturbations in the background and to estimate the light fluence inside the phantoms at the wavelength pair (760 nm, 830 nm). This enabled the spectral correction of the vessel-like absorbers' OA signals: the error in the ratio of the absorption coefficient at 830 nm to that at 760 nm was reduced from 60%-150% to 10%-20%. The results suggest that oxygen saturation (SO ) levels in arteries can be determined with <10% error and furthermore, that relative changes in vessels' SO can be monitored with even better accuracy. The outcome relies on a proper identification of the OA signals emanating from the studied vessels.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neonatology
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Physical Sciences > General Chemistry
Physical Sciences > General Materials Science
Life Sciences > General Biochemistry, Genetics and Molecular Biology
Physical Sciences > General Engineering
Physical Sciences > General Physics and Astronomy
Language:English
Date:January 2019
Deposited On:14 Mar 2019 07:50
Last Modified:29 Jul 2020 09:28
Publisher:Wiley-VCH Verlag
ISSN:1864-063X
OA Status:Hybrid
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1002/jbio.201800112
PubMed ID:30098119

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