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Wirksamkeit von Deslorelinazetat zur Läufigkeitsunterdrückung der Hündin : eine retrospektive Analyse von 102 Fällen


Palm, Julia. Wirksamkeit von Deslorelinazetat zur Läufigkeitsunterdrückung der Hündin : eine retrospektive Analyse von 102 Fällen. 2011, University of Zurich, Vetsuisse Faculty.

Abstract

Surgical neutering is the most common method used for oestrus suppression in bitches. Due to unwanted side effects, there is an increasing demand for reversible alternatives. The GnRH-agonist Deslorelin acetate (DA, Suprelorin®) is successfully used to achieve a transient infertility in male dogs and is increasingly used off-label for bitches in private practice. A retrospective study, based on an owner and private practitioner questionnaire, was performed on 102 female dogs treated with DA for oestrus suppression. Data on the success of treatment and side effects were collected and analysed. The desired effect of the treatment, the suppression of oestrus without the occurrence of metropathy (M), was achieved in 48% of cases. After treatment 35% of the dogs had clinical signs of induced oestrus (iL), 11% showed a persistent heat (DL) and 16% developed an M. The confirmed pre- treatment plasma progesterone concentration of > 5 ng/ml did not reduce the risk of iL or DL. With increasing age the risk of iL, DL and M was increased. There was a significant relationship between DL and M. Other reported side effects were pseudopregnancy (31%), coat changes (28%), increase in body weight (27%), urinary incontinence (5%) and behavioural changes (54%). Especially in young bitches with a high risk of urinary incontinence the treatment with DA offers advantages over surgical neutering. Informing the owner of possible side effects, in particular metropathy, is essential.

GnRH-agonist, Deslorelin acetate, bitch, oestrus suppression

Abstract

Surgical neutering is the most common method used for oestrus suppression in bitches. Due to unwanted side effects, there is an increasing demand for reversible alternatives. The GnRH-agonist Deslorelin acetate (DA, Suprelorin®) is successfully used to achieve a transient infertility in male dogs and is increasingly used off-label for bitches in private practice. A retrospective study, based on an owner and private practitioner questionnaire, was performed on 102 female dogs treated with DA for oestrus suppression. Data on the success of treatment and side effects were collected and analysed. The desired effect of the treatment, the suppression of oestrus without the occurrence of metropathy (M), was achieved in 48% of cases. After treatment 35% of the dogs had clinical signs of induced oestrus (iL), 11% showed a persistent heat (DL) and 16% developed an M. The confirmed pre- treatment plasma progesterone concentration of > 5 ng/ml did not reduce the risk of iL or DL. With increasing age the risk of iL, DL and M was increased. There was a significant relationship between DL and M. Other reported side effects were pseudopregnancy (31%), coat changes (28%), increase in body weight (27%), urinary incontinence (5%) and behavioural changes (54%). Especially in young bitches with a high risk of urinary incontinence the treatment with DA offers advantages over surgical neutering. Informing the owner of possible side effects, in particular metropathy, is essential.

GnRH-agonist, Deslorelin acetate, bitch, oestrus suppression

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Additional indexing

Item Type:Dissertation (monographical)
Referees:Reichler Iris M, Lutz Thomas A
Communities & Collections:05 Vetsuisse Faculty > Veterinary Clinic > Department of Farm Animals
UZH Dissertations
Dewey Decimal Classification:570 Life sciences; biology
630 Agriculture
Language:German
Place of Publication:Zürich
Date:2011
Deposited On:29 Apr 2019 16:07
Last Modified:25 Sep 2019 17:15
Number of Pages:73
OA Status:Green
Related URLs:https://www.recherche-portal.ch/primo-explore/fulldisplay?docid=ebi01_prod006673471&context=L&vid=ZAD&search_scope=default_scope&tab=default_tab&lang=de_DE (Library Catalogue)

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