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Zelluläre Antwort auf die Implantation degradierbarer Knochenersatzmaterialien


Reindl, Simone A. Zelluläre Antwort auf die Implantation degradierbarer Knochenersatzmaterialien. 2012, University of Zurich, Vetsuisse Faculty.

Abstract

The aim of this study was to histologically evaluate the cellular reaction to 33 degradable bone substitute materials implanted in a drill hole model in sheep. The different materials were based on calciumphosphate cement, calciumsulfate, hydrogel and silk and had already been classified as biocompatible in earlier studies. The histological evaluation took place 6 – 8 weeks post operationem and lymphocytes, plasma cells, macrophages and multinucleated foreign body cells (MFBC) were quantified in four different zones of the drill hole.
The degradation from peripheral to central led to a specific pattern of cells. Calciumphosphate cements were mainly degraded by macrophages, while many MFBC were found in silk-based and some of the hydrogel-based materials. Shape and size of the phagocytes were determined by the degraded material. In the disintegration process of large-molecular materials based on silk or hydrogel, MFBC were expected, but did not interfere with the biocompatibility. The formation of new bone was detected right next to MFBC. The rest of some silk-based materials were encircled by fibrous tissue, which may be connected to a lower biocompatibility.
According to the available results, this research confirms that the MFBC which were regularly encountered in the degradation of various materials are part of a normal disintegration process and not a sign of a reduced biocompatibility.

Abstract

The aim of this study was to histologically evaluate the cellular reaction to 33 degradable bone substitute materials implanted in a drill hole model in sheep. The different materials were based on calciumphosphate cement, calciumsulfate, hydrogel and silk and had already been classified as biocompatible in earlier studies. The histological evaluation took place 6 – 8 weeks post operationem and lymphocytes, plasma cells, macrophages and multinucleated foreign body cells (MFBC) were quantified in four different zones of the drill hole.
The degradation from peripheral to central led to a specific pattern of cells. Calciumphosphate cements were mainly degraded by macrophages, while many MFBC were found in silk-based and some of the hydrogel-based materials. Shape and size of the phagocytes were determined by the degraded material. In the disintegration process of large-molecular materials based on silk or hydrogel, MFBC were expected, but did not interfere with the biocompatibility. The formation of new bone was detected right next to MFBC. The rest of some silk-based materials were encircled by fibrous tissue, which may be connected to a lower biocompatibility.
According to the available results, this research confirms that the MFBC which were regularly encountered in the degradation of various materials are part of a normal disintegration process and not a sign of a reduced biocompatibility.

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Additional indexing

Item Type:Dissertation (monographical)
Referees:von Rechenberg Brigitte, Geyer Hans
Communities & Collections:05 Vetsuisse Faculty > Veterinary Clinic > Equine Department
UZH Dissertations
Dewey Decimal Classification:570 Life sciences; biology
630 Agriculture
Uncontrolled Keywords:Multinucleated foreign body cell, drill hole model, hydrogel, silk, Calciumphosphate cement
Language:German
Place of Publication:Zürich
Date:2012
Deposited On:29 Apr 2019 16:19
Last Modified:15 Apr 2021 15:00
Number of Pages:108
OA Status:Green

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