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Vitamin B12 derivatives with peptide backbones


Zhou, Kai. Vitamin B12 derivatives with peptide backbones. 2012, University of Zurich, Faculty of Science.

Abstract

Vitamin B12 is an essential biomolecule for humans and it is only produced by certain microorganisms. Its elegant, yet complex structure combined with its fascinating properties attracted research of some of the most extraordinary scientists in the past, which opened new horizons in medicine, crystallography and organic synthesis. Studies on the mechanism of B12 dependent enzymes suggest that the coordination and electrochemical properties at the cobalt centre of cobalamins are essential for its biological activity. The crucial role of cobalamins for cell replication is also attractive for developing inhibitors of B12 dependent enzymes as novel anti-proliferating drugs.

Abstract

Vitamin B12 is an essential biomolecule for humans and it is only produced by certain microorganisms. Its elegant, yet complex structure combined with its fascinating properties attracted research of some of the most extraordinary scientists in the past, which opened new horizons in medicine, crystallography and organic synthesis. Studies on the mechanism of B12 dependent enzymes suggest that the coordination and electrochemical properties at the cobalt centre of cobalamins are essential for its biological activity. The crucial role of cobalamins for cell replication is also attractive for developing inhibitors of B12 dependent enzymes as novel anti-proliferating drugs.

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Additional indexing

Item Type:Dissertation (monographical)
Referees:Zelder Felix Hubertus, Alberto Roger
Communities & Collections:UZH Dissertations
Dewey Decimal Classification:Unspecified
Language:English
Place of Publication:Zürich
Date:2012
Deposited On:16 Apr 2019 12:53
Last Modified:07 Apr 2020 07:17
Number of Pages:107
OA Status:Green
Related URLs:https://www.recherche-portal.ch/primo-explore/fulldisplay?docid=ebi01_prod007326858&context=L&vid=ZAD&search_scope=default_scope&tab=default_tab&lang=de_DE (Library Catalogue)

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