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Asquith, Christopher R M; Laitinen, Tuomo; Konstantinova, Lidia S; Tizzard, Graham; Poso, Antti; Rakitin, Oleg A; Hofmann-Lehmann, Regina; Hilton, Stephen T (2019). Investigation of the pentathiepin functionality as an inhibitor of Feline Immunodeficiency Virus (FIV) via a potential zinc ejection mechanism, as a model for HIV infection. ChemMedChem, 14(4):454-461.
A small diverse library of pentathiepin derivatives were prepared to evaluate their efficacy against the nucleocapsid protein function of the feline immunodeficiency virus (FIV) as a model for HIV, using an in vitro cell culture approach. This study led to the development of nanomolar active compounds with low toxicity.
| Item Type: | Journal Article, refereed, original work |
|---|---|
| Communities & Collections: | 05 Vetsuisse Faculty > Veterinary Clinic > Department of Clinical Diagnostics and Services
05 Vetsuisse Faculty > Center for Clinical Studies |
| Dewey Decimal Classification: | 610 Medicine & health |
| Scopus Subject Areas: | Life Sciences > Biochemistry
Life Sciences > Molecular Medicine Life Sciences > Pharmacology Life Sciences > Drug Discovery Life Sciences > General Pharmacology, Toxicology and Pharmaceutics Physical Sciences > Organic Chemistry |
| Uncontrolled Keywords: | General Pharmacology, Toxicology and Pharmaceutics, Organic Chemistry, Molecular Medicine, 1,2,3,4,5-pentathiepin; FIV; HIV; antiviral agents; nucleocapsid protein; varacin |
| Language: | English |
| Date: | 19 February 2019 |
| Deposited On: | 28 Jan 2019 09:37 |
| Last Modified: | 29 Aug 2024 03:34 |
| Publisher: | Wiley-Blackwell Publishing, Inc. |
| ISSN: | 1860-7179 |
| OA Status: | Closed |
| Publisher DOI: | https://doi.org/10.1002/cmdc.201800718 |
| PubMed ID: | 30609219 |
Asquith, Christopher R M