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Across-night dynamics in traveling sleep slow waves throughout childhood


Schoch, Sarah F; Riedner, Brady A; Deoni, Sean C; Huber, Reto; LeBourgeois, Monique K; Kurth, Salome (2018). Across-night dynamics in traveling sleep slow waves throughout childhood. Sleep, 41(11):zsy165.

Abstract

Study Objectives: Sleep slow waves behave like traveling waves and are thus a marker for brain connectivity. Across a night of sleep in adults, wave propagation is scaled down, becoming more local. Yet, it is unknown whether slow wave propagation undergoes similar across-night dynamics in childhood-a period of extensive cortical rewiring.
Methods: High-density electroencephalography (EEG; 128 channels) was recorded during sleep in three groups of healthy children: 2.0-4.9 years (n = 11), 5.0-8.9 years (n = 9) and 9.0-16.9 years (n = 9). Slow wave propagation speed, distance, and cortical involvement were quantified. To characterize across-night dynamics, the 20% most pronounced (highest amplitude) slow waves were subdivided into five time-based quintiles.
Results: We found indications that slow wave propagation distance decreased across a night of sleep. We observed an interesting interaction of across-night slow wave propagation dynamics with age (p < 0.05). When comparing the first and last quintiles, there was a trend level difference between age groups: 2- to 4.9-year-old children showed an 11.9% across-night decrease in slow wave propagation distance, which was not observed in the older two age groups. Regardless of age, cortical involvement decreased by 10.4%-23.7% across a night of sleep. No across-night changes were observed in slow wave speed.
Conclusions: Findings provide evidence that signatures of brain connectivity undergo across-night dynamics specific to maturational periods. These results suggest that across-night dynamics in slow wave propagation distance reflect heightened plasticity in underlying cerebral networks specific to developmental periods.

Abstract

Study Objectives: Sleep slow waves behave like traveling waves and are thus a marker for brain connectivity. Across a night of sleep in adults, wave propagation is scaled down, becoming more local. Yet, it is unknown whether slow wave propagation undergoes similar across-night dynamics in childhood-a period of extensive cortical rewiring.
Methods: High-density electroencephalography (EEG; 128 channels) was recorded during sleep in three groups of healthy children: 2.0-4.9 years (n = 11), 5.0-8.9 years (n = 9) and 9.0-16.9 years (n = 9). Slow wave propagation speed, distance, and cortical involvement were quantified. To characterize across-night dynamics, the 20% most pronounced (highest amplitude) slow waves were subdivided into five time-based quintiles.
Results: We found indications that slow wave propagation distance decreased across a night of sleep. We observed an interesting interaction of across-night slow wave propagation dynamics with age (p < 0.05). When comparing the first and last quintiles, there was a trend level difference between age groups: 2- to 4.9-year-old children showed an 11.9% across-night decrease in slow wave propagation distance, which was not observed in the older two age groups. Regardless of age, cortical involvement decreased by 10.4%-23.7% across a night of sleep. No across-night changes were observed in slow wave speed.
Conclusions: Findings provide evidence that signatures of brain connectivity undergo across-night dynamics specific to maturational periods. These results suggest that across-night dynamics in slow wave propagation distance reflect heightened plasticity in underlying cerebral networks specific to developmental periods.

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Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Children's Hospital Zurich > Medical Clinic
04 Faculty of Medicine > Psychiatric University Hospital Zurich > Department of Child and Adolescent Psychiatry
04 Faculty of Medicine > University Hospital Zurich > Clinic for Pneumology
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Neurology (clinical)
Health Sciences > Physiology (medical)
Language:English
Date:1 November 2018
Deposited On:22 Feb 2019 13:50
Last Modified:01 Nov 2021 14:19
Publisher:American Academy of Sleep Medicine
ISSN:0161-8105
OA Status:Hybrid
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1093/sleep/zsy165
PubMed ID:30169809

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