Header

UZH-Logo

Maintenance Infos

Unexplored therapeutic opportunities in the human genome


Oprea, Tudor I; Bologa, Cristian G; Brunak, Søren; et al; von Mering, Christian (2018). Unexplored therapeutic opportunities in the human genome. Nature Reviews. Drug Discovery, 17(5):317-332.

Abstract

A large proportion of biomedical research and the development of therapeutics is focused on a small fraction of the human genome. In a strategic effort to map the knowledge gaps around proteins encoded by the human genome and to promote the exploration of currently understudied, but potentially druggable, proteins, the US National Institutes of Health launched the Illuminating the Druggable Genome (IDG) initiative in 2014. In this article, we discuss how the systematic collection and processing of a wide array of genomic, proteomic, chemical and disease-related resource data by the IDG Knowledge Management Center have enabled the development of evidence-based criteria for tracking the target development level (TDL) of human proteins, which indicates a substantial knowledge deficit for approximately one out of three proteins in the human proteome. We then present spotlights on the TDL categories as well as key drug target classes, including G protein-coupled receptors, protein kinases and ion channels, which illustrate the nature of the unexplored opportunities for biomedical research and therapeutic development.

Abstract

A large proportion of biomedical research and the development of therapeutics is focused on a small fraction of the human genome. In a strategic effort to map the knowledge gaps around proteins encoded by the human genome and to promote the exploration of currently understudied, but potentially druggable, proteins, the US National Institutes of Health launched the Illuminating the Druggable Genome (IDG) initiative in 2014. In this article, we discuss how the systematic collection and processing of a wide array of genomic, proteomic, chemical and disease-related resource data by the IDG Knowledge Management Center have enabled the development of evidence-based criteria for tracking the target development level (TDL) of human proteins, which indicates a substantial knowledge deficit for approximately one out of three proteins in the human proteome. We then present spotlights on the TDL categories as well as key drug target classes, including G protein-coupled receptors, protein kinases and ion channels, which illustrate the nature of the unexplored opportunities for biomedical research and therapeutic development.

Statistics

Citations

Dimensions.ai Metrics
43 citations in Web of Science®
46 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

81 downloads since deposited on 22 Feb 2019
75 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:07 Faculty of Science > Institute of Molecular Life Sciences
Dewey Decimal Classification:570 Life sciences; biology
Language:English
Date:May 2018
Deposited On:22 Feb 2019 14:24
Last Modified:29 Oct 2019 08:08
Publisher:Nature Publishing Group
ISSN:1474-1776
Additional Information:Erratum in Unexplored therapeutic opportunities in the human genome. [Nat Rev Drug Discov. 2018]
OA Status:Green
Publisher DOI:https://doi.org/10.1038/nrd.2018.14
PubMed ID:29472638

Download

Green Open Access

Download PDF  'Unexplored therapeutic opportunities in the human genome'.
Preview
Content: Published Version
Filetype: PDF
Size: 873kB
View at publisher