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68Ga-PSMA-11 PET/MR Can Be False Positive in Normal Prostatic Tissue


Ferraro, Daniela A; Rupp, Niels J; Donati, Olivio F; Messerli, Michael; Eberli, Daniel; Burger, Irene A (2019). 68Ga-PSMA-11 PET/MR Can Be False Positive in Normal Prostatic Tissue. Clinical Nuclear Medicine, 44(4):e291-e293.

Abstract

Prostate-specific membrane antigen (PSMA) is a transmembrane glycoprotein expressed in the cytosol of normal prostate tissue and highly overexpressed on the membrane of prostate cancer, therefore increasingly used to image prostate cancer. We report a case of a 65-year-old man with two focal PSMA-positive areas on a Ga-PSMA-11 PET/MR, one corresponding to a prostate carcinoma (Gleason score 4 + 3) and another region without any evidence of malignancy, but with corresponding high PSMA-expression on immunohistochemistry.

Abstract

Prostate-specific membrane antigen (PSMA) is a transmembrane glycoprotein expressed in the cytosol of normal prostate tissue and highly overexpressed on the membrane of prostate cancer, therefore increasingly used to image prostate cancer. We report a case of a 65-year-old man with two focal PSMA-positive areas on a Ga-PSMA-11 PET/MR, one corresponding to a prostate carcinoma (Gleason score 4 + 3) and another region without any evidence of malignancy, but with corresponding high PSMA-expression on immunohistochemistry.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Diagnostic and Interventional Radiology
04 Faculty of Medicine > University Hospital Zurich > Institute of Pathology and Molecular Pathology
04 Faculty of Medicine > University Hospital Zurich > Urological Clinic
04 Faculty of Medicine > University Hospital Zurich > Clinic for Nuclear Medicine
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:25 January 2019
Deposited On:15 Mar 2019 07:53
Last Modified:17 Sep 2019 20:08
Publisher:Lippincott Williams & Wilkins
ISSN:0363-9762
OA Status:Closed
Publisher DOI:https://doi.org/10.1097/RLU.0000000000002473
PubMed ID:30688746

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Embargo till: 2020-03-15