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Challenges and needs in experimental therapies for multiple sclerosis


Lutterotti, Andreas (2018). Challenges and needs in experimental therapies for multiple sclerosis. Current Opinion in Neurology, 31(3):263-267.

Abstract

PURPOSE OF REVIEW Despite dramatic advances in the treatment of people with multiple sclerosis over the last decade, several unmet medical needs still remain and should be approached with new compounds in experimental clinical trials. The prerequisites for successful clinical trials in multiple sclerosis have changed considerably over time and activities have started to improve clinical development of new drugs in several aspects including trial designs, patient selection and outcome parameters. This review will address some of the challenges in early experimental trials in multiple sclerosis and recent approaches in the field.
RECENT FINDINGS Highly intensive treatment regimens like autologous hematopoietic stem cell transplantation provide evidence for sustained long-term treatment effects in multiple sclerosis patients. Several different approaches towards neuroprotection and remyelination have entered the clinical phase and demonstrated that stabilization, even improvement of disability is achievable in short-term studies.
SUMMARY New therapeutic strategies have entered the clinic with the prospects of long-term efficacy and enduring effects on disability progression.

Abstract

PURPOSE OF REVIEW Despite dramatic advances in the treatment of people with multiple sclerosis over the last decade, several unmet medical needs still remain and should be approached with new compounds in experimental clinical trials. The prerequisites for successful clinical trials in multiple sclerosis have changed considerably over time and activities have started to improve clinical development of new drugs in several aspects including trial designs, patient selection and outcome parameters. This review will address some of the challenges in early experimental trials in multiple sclerosis and recent approaches in the field.
RECENT FINDINGS Highly intensive treatment regimens like autologous hematopoietic stem cell transplantation provide evidence for sustained long-term treatment effects in multiple sclerosis patients. Several different approaches towards neuroprotection and remyelination have entered the clinical phase and demonstrated that stabilization, even improvement of disability is achievable in short-term studies.
SUMMARY New therapeutic strategies have entered the clinic with the prospects of long-term efficacy and enduring effects on disability progression.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Life Sciences > Neurology
Health Sciences > Neurology (clinical)
Language:English
Date:June 2018
Deposited On:11 Feb 2019 09:13
Last Modified:29 Jul 2020 09:51
Publisher:Lippincott Williams & Wilkins
ISSN:1080-8248
OA Status:Green
Publisher DOI:https://doi.org/10.1097/WCO.0000000000000560
PubMed ID:29608446

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