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Estimates of age-dependent cutoffs for pathological brain volume loss using SIENA/FSL—a longitudinal brain volumetry study in healthy adults

Opfer, Roland; Ostwaldt, Ann-Christin; Sormani, Maria Pia; Gocke, Carola; Walker-Egger, Christine; Manogaran, Praveena; De Stefano, Nicola; Schippling, Sven (2018). Estimates of age-dependent cutoffs for pathological brain volume loss using SIENA/FSL—a longitudinal brain volumetry study in healthy adults. Neurobiology of Aging, 65:1-6.

Abstract

Brain volume loss (BVL) has gained increasing interest for monitoring tissue damage in neurodegenerative diseases including multiple sclerosis (MS). In this longitudinal study, 117 healthy participants (age range 37.3-82.6 years) received at least 2 magnetic resonance imaging examinations. BVL (in %) was determined with the Structural Image Evaluation using Normalisation of Atrophy/FMRIB Software Library and annualized. Mean BVL per year was 0.15%, 0.30%, 0.46%, and 0.61% at ages 45, 55, 65, and 75 years, respectively. The corresponding BVL per year values of the age-dependent 95th percentiles were 0.52%, 0.77%, 1.05% and 1.45%. Pathological BVL can be assumed if an individual BVL per year exceeds these thresholds for a given age. The mean BVL per year determined in this longitudinal study was consistent with results from a cross-sectional study that was published recently. The cut-off for a pathological BVL per year at the age of 45 years (0.52%) was consistent with the cut-off suggested previously to distinguish between physiological and pathological BVL in MS patients. Different cut-off values, however, need to be considered when interpreting BVL assessed in cohorts of higher ages.

Additional indexing

Other titles:Estimates of age-dependent cutoffs for pathological brain volume loss using SIENA/FSL-a longitudinal brain volumetry study in healthy adults
Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Life Sciences > General Neuroscience
Life Sciences > Aging
Health Sciences > Neurology (clinical)
Life Sciences > Developmental Biology
Health Sciences > Geriatrics and Gerontology
Language:English
Date:May 2018
Deposited On:11 Feb 2019 09:18
Last Modified:21 Oct 2024 01:35
Publisher:Elsevier
ISSN:0197-4580
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.neurobiolaging.2017.12.024
PubMed ID:29407463
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