Header

UZH-Logo

Maintenance Infos

Transcatheter Aortic Valve Replacement and Concomitant Mitral Regurgitation


Stähli, Barbara E; Reinthaler, Markus; Leistner, David M; Landmesser, Ulf; Lauten, Alexander (2018). Transcatheter Aortic Valve Replacement and Concomitant Mitral Regurgitation. Frontiers in cardiovascular medicine, 5:74.

Abstract

Mitral regurgitation frequently coexists in patients with severe aortic stenosis. Patients with moderate to severe mitral regurgitation at the time of transcatheter aortic valve replacement are at increased risk of future adverse events. Whether concomitant mitral regurgitation is independently associated with worse outcomes after TAVR remains a matter of debate. The optimal therapeutic strategy in these patients-TAVR with evidence-based heart failure therapy, combined TAVR and transcatheter mitral valve intervention, or staged transcatheter therapies-is ill-defined, and guideline-based recommendations in patients at increased risk for open heart surgery are lacking. Hence, a thorough evaluation of the aortic and mitral valve anatomy and function, along with an in-depth assessment of the patients' baseline risk profile, provides the basis for an individualized treatment approach. The aim of this review is therefore to give an overview of the current literature on mitral regurgitation in TAVR, focusing on different diagnostic and therapeutic strategies and optimal clinical decision making.

Abstract

Mitral regurgitation frequently coexists in patients with severe aortic stenosis. Patients with moderate to severe mitral regurgitation at the time of transcatheter aortic valve replacement are at increased risk of future adverse events. Whether concomitant mitral regurgitation is independently associated with worse outcomes after TAVR remains a matter of debate. The optimal therapeutic strategy in these patients-TAVR with evidence-based heart failure therapy, combined TAVR and transcatheter mitral valve intervention, or staged transcatheter therapies-is ill-defined, and guideline-based recommendations in patients at increased risk for open heart surgery are lacking. Hence, a thorough evaluation of the aortic and mitral valve anatomy and function, along with an in-depth assessment of the patients' baseline risk profile, provides the basis for an individualized treatment approach. The aim of this review is therefore to give an overview of the current literature on mitral regurgitation in TAVR, focusing on different diagnostic and therapeutic strategies and optimal clinical decision making.

Statistics

Citations

Altmetrics

Downloads

21 downloads since deposited on 05 Feb 2019
21 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Cardiology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:2018
Deposited On:05 Feb 2019 13:37
Last Modified:25 Sep 2019 00:20
Publisher:Frontiers Research Foundation
ISSN:2297-055X
OA Status:Gold
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.3389/fcvm.2018.00074
PubMed ID:29971238

Download

Download PDF  'Transcatheter Aortic Valve Replacement and Concomitant Mitral Regurgitation'.
Preview
Content: Published Version
Filetype: PDF
Size: 590kB
View at publisher
Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)