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The management of lomustine overdose in malignant glioma patients


Wirsching, Hans-Georg; Tritschler, Isabel; Palla, Antonella; Renner, Christoph; Weller, Michael; Tabatabai, Ghazaleh (2014). The management of lomustine overdose in malignant glioma patients. Neuro-Oncology Practice, 1(4):178-183.

Abstract

Lomustine is an oral alkylating drug commonly used for brain tumor patients. Recently, the lomustine-containing PCV polychemotherapy regime (procarbazine, CCNU/lomustine, and vincristine) in combination with radiotherapy has become the standard of care for anaplastic oligodendroglioma with 1p/19q codeletion and high-risk low-grade glioma. Here, we review the literature of all reported cases of lomustine overdose, highlight complications by exemplifying a case of inadvertent lomustine overdose, and outline the management of this potential complication of outpatient PCV therapy.

Abstract

Lomustine is an oral alkylating drug commonly used for brain tumor patients. Recently, the lomustine-containing PCV polychemotherapy regime (procarbazine, CCNU/lomustine, and vincristine) in combination with radiotherapy has become the standard of care for anaplastic oligodendroglioma with 1p/19q codeletion and high-risk low-grade glioma. Here, we review the literature of all reported cases of lomustine overdose, highlight complications by exemplifying a case of inadvertent lomustine overdose, and outline the management of this potential complication of outpatient PCV therapy.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neurology
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:December 2014
Deposited On:11 Feb 2019 08:26
Last Modified:11 Feb 2019 18:55
Publisher:Oxford University Press
ISSN:2054-2577
OA Status:Hybrid
Publisher DOI:https://doi.org/10.1093/nop/npu023
PubMed ID:26034630

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