Header

UZH-Logo

Maintenance Infos

Microglia-Mediated Synapse Loss in Alzheimer's Disease


Rajendran, Lawrence; Paolicelli, Rosa C (2018). Microglia-Mediated Synapse Loss in Alzheimer's Disease. Journal of Neuroscience, 38(12):2911-2919.

Abstract

Microglia are emerging as key players in neurodegenerative diseases, such as Alzheimer's disease (AD). Thus far, microglia have rather been known as modulator of neurodegeneration with functions limited to neuroinflammation and release of neurotoxic molecules. However, several recent studies have demonstrated a direct role of microglia in "neuro" degeneration observed in AD by promoting phagocytosis of neuronal, in particular, synaptic structures. While some of the studies address the involvement of the β-amyloid peptides in the process, studies also indicate that this could occur independent of amyloid, further elevating the importance of microglia in AD. Here we review these recent studies and also speculate about the possible cellular mechanisms, and how they could be regulated by risk genes and sleep. Finally, we deliberate on possible avenues for targeting microglia-mediated synapse loss for therapy and prevention..

Abstract

Microglia are emerging as key players in neurodegenerative diseases, such as Alzheimer's disease (AD). Thus far, microglia have rather been known as modulator of neurodegeneration with functions limited to neuroinflammation and release of neurotoxic molecules. However, several recent studies have demonstrated a direct role of microglia in "neuro" degeneration observed in AD by promoting phagocytosis of neuronal, in particular, synaptic structures. While some of the studies address the involvement of the β-amyloid peptides in the process, studies also indicate that this could occur independent of amyloid, further elevating the importance of microglia in AD. Here we review these recent studies and also speculate about the possible cellular mechanisms, and how they could be regulated by risk genes and sleep. Finally, we deliberate on possible avenues for targeting microglia-mediated synapse loss for therapy and prevention..

Statistics

Citations

Dimensions.ai Metrics
90 citations in Web of Science®
82 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

21 downloads since deposited on 05 Mar 2019
5 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > Institute for Regenerative Medicine (IREM)
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Life Sciences > General Neuroscience
Language:English
Date:21 March 2018
Deposited On:05 Mar 2019 15:23
Last Modified:29 Jul 2020 10:02
Publisher:Society for Neuroscience
ISSN:0270-6474
OA Status:Hybrid
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1523/JNEUROSCI.1136-17.2017
PubMed ID:29563239

Download

Hybrid Open Access

Download PDF  'Microglia-Mediated Synapse Loss in Alzheimer's Disease'.
Preview
Content: Published Version
Filetype: PDF
Size: 580kB
View at publisher
Licence: Creative Commons: Attribution 4.0 International (CC BY 4.0)