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Sex differences in functional and molecular neuroimaging biomarkers of Alzheimer's disease in cognitively normal older adults with subjective memory complaints


Cavedo, Enrica; Chiesa, Patrizia A; Houot, Marion; Ferretti, Maria Teresa; Grothe, Michel J; Teipel, Stefan J; Lista, Simone; Habert, Marie-Odile; Potier, Marie-Claude; Dubois, Bruno; Hampel, Harald (2018). Sex differences in functional and molecular neuroimaging biomarkers of Alzheimer's disease in cognitively normal older adults with subjective memory complaints. Alzheimer's & Dementia, 14(9):1204-1215.

Abstract

INTRODUCTION
Observational multimodal neuroimaging studies indicate sex differences in Alzheimer's disease pathophysiological markers.
METHODS
Positron emission tomography brain amyloid load, neurodegeneration (hippocampus and basal forebrain volumes adjusted to total intracranial volume, cortical thickness, and 2-deoxy-2-[fluorine-18]fluoro-D-glucose-positron emission tomography metabolism), and brain resting-state functional connectivity were analyzed in 318 cognitively intact older adults from the INSIGHT-preAD cohort (female n = 201, male n = 117). A linear mixed-effects model was performed to investigate sex effects and sex∗apolipoprotein E genotype interaction on each marker as well as sex∗amyloid group interaction for non-amyloid markers.
RESULTS
Men compared with women showed higher anterior cingulate cortex amyloid load (P = .009), glucose hypometabolism in the precuneus (P = .027), posterior cingulate (P < .001) and inferior parietal (P = .043) cortices, and lower resting-state functional connectivity in the default mode network (P = .024). No brain volumetric markers showed differences between men and women. Sex∗apolipoprotein E genotype and sex∗amyloid status interactions were not significant.
DISCUSSION
Our findings suggest that cognitively intact older men compared with women have higher resilience to pathophysiological processes of Alzheimer's disease.

Abstract

INTRODUCTION
Observational multimodal neuroimaging studies indicate sex differences in Alzheimer's disease pathophysiological markers.
METHODS
Positron emission tomography brain amyloid load, neurodegeneration (hippocampus and basal forebrain volumes adjusted to total intracranial volume, cortical thickness, and 2-deoxy-2-[fluorine-18]fluoro-D-glucose-positron emission tomography metabolism), and brain resting-state functional connectivity were analyzed in 318 cognitively intact older adults from the INSIGHT-preAD cohort (female n = 201, male n = 117). A linear mixed-effects model was performed to investigate sex effects and sex∗apolipoprotein E genotype interaction on each marker as well as sex∗amyloid group interaction for non-amyloid markers.
RESULTS
Men compared with women showed higher anterior cingulate cortex amyloid load (P = .009), glucose hypometabolism in the precuneus (P = .027), posterior cingulate (P < .001) and inferior parietal (P = .043) cortices, and lower resting-state functional connectivity in the default mode network (P = .024). No brain volumetric markers showed differences between men and women. Sex∗apolipoprotein E genotype and sex∗amyloid status interactions were not significant.
DISCUSSION
Our findings suggest that cognitively intact older men compared with women have higher resilience to pathophysiological processes of Alzheimer's disease.

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Additional indexing

Contributors:INSIGHT-preAD Study Group, Alzheimer Precision Medicine Initiative (APMI)
Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute for Regenerative Medicine (IREM)
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Epidemiology
Health Sciences > Health Policy
Life Sciences > Developmental Neuroscience
Health Sciences > Neurology (clinical)
Health Sciences > Geriatrics and Gerontology
Health Sciences > Psychiatry and Mental Health
Life Sciences > Cellular and Molecular Neuroscience
Language:English
Date:September 2018
Deposited On:05 Mar 2019 15:24
Last Modified:29 Jul 2020 10:02
Publisher:Elsevier
ISSN:1552-5260
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.jalz.2018.05.014
PubMed ID:30201102

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