Münz, C (2008). Non-cytotoxic protection by human NK cells in mucosal secondary lymphoid tissues. European Journal of Immunology, 38(11):2946-2948.
Even though NK cells have been named for their spontaneous cytotoxicity, a large subpopulation of human NK cells primarily responds to activation with cytokine secretion and not killing. These CD56brightCD16(-) NK cells are abundant in secondary lymphoid tissues, can restrict pathogens that have breached mucosal barriers, and assist Th1 polarization during immune response priming. This exciting new aspect of NK-cell biology is discussed in this viewpoint.
Even though NK cells have been named for their spontaneous cytotoxicity, a large subpopulation of human NK cells primarily responds to activation with cytokine secretion and not killing. These CD56brightCD16(-) NK cells are abundant in secondary lymphoid tissues, can restrict pathogens that have breached mucosal barriers, and assist Th1 polarization during immune response priming. This exciting new aspect of NK-cell biology is discussed in this viewpoint.
| Item Type: | Journal Article, refereed, further contribution |
|---|---|
| Communities & Collections: | 04 Faculty of Medicine > Institute of Experimental Immunology |
| Dewey Decimal Classification: | 570 Life sciences; biology
610 Medicine & health |
| Scopus Subject Areas: | Health Sciences > Immunology and Allergy
Life Sciences > Immunology |
| Language: | English |
| Date: | 2008 |
| Deposited On: | 11 Jan 2010 13:13 |
| Last Modified: | 25 Jun 2022 22:33 |
| Publisher: | Wiley-Blackwell |
| ISSN: | 0014-2980 |
| Additional Information: | The definitive version is available at www.blackwell-synergy.com |
| OA Status: | Closed |
| Publisher DOI: | https://doi.org/10.1002/eji.200838849 |
| PubMed ID: | 18979517 |
Münz, C