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Image reversal reactive immersion lithography improves the detection limit of focal molography


Frutiger, Andreas; Tschannen, Cla Duri; Blickenstorfer, Yves; Reichmuth, Andreas M; Fattinger, Christof; Vörös, Janos (2018). Image reversal reactive immersion lithography improves the detection limit of focal molography. Optics letters, 43(23):5801-5804.

Abstract

Focal molography is a label-free optical biosensing method that relies on a coherent pattern of binding sites for biomolecular interaction analysis. Reactive immersion lithography (RIL) is central to the patterning of molographic chips but has potential for improvements. Here, we show that applying the idea of image reversal to RIL enables the fabrication of coherent binding patterns of increased quality (i.e., higher analyte efficiency). Thereby the detection limit of focal molography in biological assays can be improved.

Abstract

Focal molography is a label-free optical biosensing method that relies on a coherent pattern of binding sites for biomolecular interaction analysis. Reactive immersion lithography (RIL) is central to the patterning of molographic chips but has potential for improvements. Here, we show that applying the idea of image reversal to RIL enables the fabrication of coherent binding patterns of increased quality (i.e., higher analyte efficiency). Thereby the detection limit of focal molography in biological assays can be improved.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > Institute of Biomedical Engineering
Dewey Decimal Classification:170 Ethics
610 Medicine & health
Uncontrolled Keywords:Atomic and Molecular Physics, and Optics
Language:English
Date:1 December 2018
Deposited On:06 Mar 2019 08:25
Last Modified:25 Sep 2019 00:23
Publisher:Optical Society of America
ISSN:0146-9592
OA Status:Closed
Publisher DOI:https://doi.org/10.1364/ol.43.005801
PubMed ID:30499945

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