Header

UZH-Logo

Maintenance Infos

Placental contribution to the endocrinology of gestation and parturition


Schuler, Gerhard; Fürbass, Rainer; Klisch, Karl (2018). Placental contribution to the endocrinology of gestation and parturition. Animal Reproduction, 15(Suppl 1):822-842.

Abstract

In addition to many other functions, the placenta is a source of a vast number of autocrine, paracrine and endocrine factors. However, the spectrum of placental regulatory factors, their concentrations, gestational profiles and roles may differ considerably even between phylogenetically closely related species. Depending on the species, placental regulatory factors of a broad range of molecule classes have been found including (glyco-)proteins, peptides, steroids and prostaglandins. Local placental regulatory factors are especially important for the dialogue between the fetal and the maternal compartment immediately at the feto-maternal borderline and for the control of growth, differentiation and functions of the placenta itself. Moreover, placental hormones in a proper sense may also have effects in more remote targets within the maternal compartment, serving functions such as pregnancy-specific adaptations of maternal circulation, provision of hemotrophe to the fetus or the development and function of the mammary gland. Functions of placental hormones in the fetus proper are less clear but may be especially important before the establishment of a functional fetal endocrine system and near term within the highly species-specific networks of signals preparing and initiating parturition. This review takes a comparative view on the situation in different domestic animals focusing on ruminants and on placental hormones occurring at significant concentrations in the maternal circulation.

Abstract

In addition to many other functions, the placenta is a source of a vast number of autocrine, paracrine and endocrine factors. However, the spectrum of placental regulatory factors, their concentrations, gestational profiles and roles may differ considerably even between phylogenetically closely related species. Depending on the species, placental regulatory factors of a broad range of molecule classes have been found including (glyco-)proteins, peptides, steroids and prostaglandins. Local placental regulatory factors are especially important for the dialogue between the fetal and the maternal compartment immediately at the feto-maternal borderline and for the control of growth, differentiation and functions of the placenta itself. Moreover, placental hormones in a proper sense may also have effects in more remote targets within the maternal compartment, serving functions such as pregnancy-specific adaptations of maternal circulation, provision of hemotrophe to the fetus or the development and function of the mammary gland. Functions of placental hormones in the fetus proper are less clear but may be especially important before the establishment of a functional fetal endocrine system and near term within the highly species-specific networks of signals preparing and initiating parturition. This review takes a comparative view on the situation in different domestic animals focusing on ruminants and on placental hormones occurring at significant concentrations in the maternal circulation.

Statistics

Citations

Dimensions.ai Metrics
7 citations in Web of Science®
6 citations in Scopus®
Google Scholar™

Altmetrics

Downloads

134 downloads since deposited on 07 Feb 2019
121 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Veterinary Anatomy
Dewey Decimal Classification:570 Life sciences; biology
Scopus Subject Areas:Life Sciences > Animal Science and Zoology
Health Sciences > General Veterinary
Uncontrolled Keywords:Animal Science and Zoology, General Veterinary, gonadotrophins, placenta, placental lactogen, relaxin, steroids.
Language:English
Date:1 January 2018
Deposited On:07 Feb 2019 19:44
Last Modified:29 Jul 2020 10:05
Publisher:Brazilian College of Animal Reproduction
ISSN:1806-9614
OA Status:Gold
Free access at:Publisher DOI. An embargo period may apply.
Publisher DOI:https://doi.org/10.21451/1984-3143-ar2018-0015

Download

Gold Open Access

Download PDF  'Placental contribution to the endocrinology of gestation and parturition'.
Preview
Content: Published Version
Language: English
Filetype: PDF
Size: 1MB
View at publisher