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Atypical cowpox virus infection in a series of cats


Jungwirth, N; Puff, C; Köster, K; Mischke, R; Meyer, H; Stark, A; Thoma, B; Zöller, G; Seehusen, F; Hewicker-Trautwein, M; Beineke, A; Baumgärtner, W; Wohlsein, P (2018). Atypical cowpox virus infection in a series of cats. Journal of Comparative Pathology, 158:71-76.

Abstract

Within 4 weeks, five cats with skin lesions affecting the hindlimbs and mainly consisting of oedema, hyperaemia and plaque-like alterations were presented to the same veterinary clinic. The cats were suffering from lameness, trauma, renal insufficiency or complicated tail amputation. Although the lesions seemed unusual for a poxvirus infection, microscopical examination of biopsy samples or specimens taken during necropsy examination revealed ballooning degeneration of keratinocytes with eosinophilic, cytoplasmic inclusion bodies indicative of an orthopoxvirus infection. Cowpox virus infection was verified using immunohistochemistry and virus isolation. Molecular analysis revealed identical haemagglutinin gene sequences in four cases and spatiotemporal circumstances in some cases pointed to hospital-acquired transmission. Unusual manifestations of feline cowpox may have an unexpected risk for human infection.

Abstract

Within 4 weeks, five cats with skin lesions affecting the hindlimbs and mainly consisting of oedema, hyperaemia and plaque-like alterations were presented to the same veterinary clinic. The cats were suffering from lameness, trauma, renal insufficiency or complicated tail amputation. Although the lesions seemed unusual for a poxvirus infection, microscopical examination of biopsy samples or specimens taken during necropsy examination revealed ballooning degeneration of keratinocytes with eosinophilic, cytoplasmic inclusion bodies indicative of an orthopoxvirus infection. Cowpox virus infection was verified using immunohistochemistry and virus isolation. Molecular analysis revealed identical haemagglutinin gene sequences in four cases and spatiotemporal circumstances in some cases pointed to hospital-acquired transmission. Unusual manifestations of feline cowpox may have an unexpected risk for human infection.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Veterinary Pathology
Dewey Decimal Classification:570 Life sciences; biology
Uncontrolled Keywords:Pathology and Forensic Medicine, General Veterinary, cat; cowpox; orthopox; unusual presentation
Language:English
Date:1 January 2018
Deposited On:07 Feb 2019 19:47
Last Modified:07 Feb 2019 19:48
Publisher:Elsevier
ISSN:0021-9975
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.jcpa.2017.12.003
PubMed ID:29422319
Project Information:
  • : FunderH2020
  • : Grant ID643476
  • : Project TitleCOMPARE - COllaborative Management Platform for detection and Analyses of (Re-)emerging and foodborne outbreaks in Europe

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