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Recent applications of a single quadrupole mass spectrometer in 11C, 18F and radiometal chemistry

Collier, Thomas L; Dahl, Kenneth; Stephenson, Nickeisha A; Holland, Jason P; Riley, Adam; Liang, Steven H; Vasdev, Neil (2018). Recent applications of a single quadrupole mass spectrometer in 11C, 18F and radiometal chemistry. Journal of Fluorine Chemistry, 210:46-55.

Abstract

Mass spectrometry (MS) has longstanding applications in radiochemistry laboratories, stemming from carbon-dating. However, research on the development of radiotracers for molecular imaging with either positron emission tomography (PET) or single photon emission computed tomography has yet to take full advantage of MS. This inertia has been attributed to the relatively low concentrations of radiopharmaceutical formulations and lack of access to the required MS equipment due to the high costs for purchase and maintenance of specialized MS systems. To date, single quadrupole (SQ)-MS coupled to liquid chromatography (LC) systems is the main form of MS that has been used in radiochemistry laboratories. These LC–MS systems are primarily used for assessing the chemical purity of radiolabeling precursor or standard molecules but also have applications in the determination of metabolites. Herein, we highlight personal experiences using a compact SQ-MS in our PET radiochemistry laboratories, to monitor the small amounts of carrier observed in most radiotracer preparations, even at high molar activities. The use of a SQ-MS in the observation of the low mass associated with non-radioactive species which are formed along with the radiotracer from the trace amounts of carrier found is demonstrated. Herein, we describe a pre-concentration system to detect dilute radiopharmaceutical formulations and metabolite analyses by SQ-MS. Selected examples where SQ-MS was critical for optimization of radiochemical reactions and for unequivocal characterization of radiotracers are showcased. We also illustrate examples where SQ-MS can be applied in identification of radiometal complexes and development of a new purification methodology for Pd-catalyzed radiofluorination reactions, shedding light on the identity of metal complexes present in the labelling solution.

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:07 Faculty of Science > Department of Chemistry
Dewey Decimal Classification:540 Chemistry
Scopus Subject Areas:Life Sciences > Biochemistry
Physical Sciences > Environmental Chemistry
Physical Sciences > Physical and Theoretical Chemistry
Physical Sciences > Organic Chemistry
Physical Sciences > Inorganic Chemistry
Uncontrolled Keywords:Physical and Theoretical Chemistry, Inorganic Chemistry, Organic Chemistry, Biochemistry, Environmental Chemistry
Language:English
Date:1 June 2018
Deposited On:07 Mar 2019 08:25
Last Modified:21 Oct 2024 01:36
Publisher:Elsevier
ISSN:0022-1139
OA Status:Hybrid
Publisher DOI:https://doi.org/10.1016/j.jfluchem.2018.02.009
Project Information:
  • Funder: SNSF
  • Grant ID: PP00P2_163683
  • Project Title: Advanced radiochemical methods for multi-modal imaging with nanomedicines
  • Funder: H2020
  • Grant ID: 676904
  • Project Title: Developing multi-modality nanomedicines for targeted annotation of oncogenic signaling pathways
  • Funder: ERC
  • Grant ID:
  • Project Title: ERC-StG-2015
  • Funder: S Department of Energy
  • Grant ID: DE-SC0015556
  • Project Title: R&D Isotope Program Project grant
  • Funder: National Institute on Aging
  • Grant ID: R01AG054473
  • Project Title:
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  • Licence: Creative Commons: Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)

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