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Cronobacter spp.- opportunistic foodborne pathogens: an update on evolution, osmotic adaptation and pathogenesis


Lehner, Angelika; Tall, Ben; Fanning, Séamus; Srikumar, S (2018). Cronobacter spp.- opportunistic foodborne pathogens: an update on evolution, osmotic adaptation and pathogenesis. Current Clinical Microbiology Reports, 5(2):97-105.

Abstract

Purpose of Review: Cronobacter spp. are opportunistic, foodborne pathogens capable of causing severe illnesses predom- inantly in premature and low-birth-weight infants. These organisms have evolved features, which aid them to survive under harsh environmental conditions but may also contribute to pathogenesis during infection. In this review, we highlight efforts to study genetic diversity and evolutionary aspects, osmotic adaptation and pathogenesis of these pathogens.
Recent Findings: Next-generation genome sequencing-based techniques elucidated a species-level bidirectional divergence driven by niche adaptation in Cronobacter spp. Whole genome comparisons and proteomics revealed genes and pathways contributing to the survival and persistence phenotype in low-moisture environments. In silico genome comparisons and appli- cation of suitable in vivo models provided answers to pathogenesis-related questions.
Summary: Development and application of innovative molecular techniques and in vivo infection models have shed light on how Cronobacter spp. adapt to challenges experienced in natural, food processing and host-related environments.

Abstract

Purpose of Review: Cronobacter spp. are opportunistic, foodborne pathogens capable of causing severe illnesses predom- inantly in premature and low-birth-weight infants. These organisms have evolved features, which aid them to survive under harsh environmental conditions but may also contribute to pathogenesis during infection. In this review, we highlight efforts to study genetic diversity and evolutionary aspects, osmotic adaptation and pathogenesis of these pathogens.
Recent Findings: Next-generation genome sequencing-based techniques elucidated a species-level bidirectional divergence driven by niche adaptation in Cronobacter spp. Whole genome comparisons and proteomics revealed genes and pathways contributing to the survival and persistence phenotype in low-moisture environments. In silico genome comparisons and appli- cation of suitable in vivo models provided answers to pathogenesis-related questions.
Summary: Development and application of innovative molecular techniques and in vivo infection models have shed light on how Cronobacter spp. adapt to challenges experienced in natural, food processing and host-related environments.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Food Safety and Hygiene
Dewey Decimal Classification:570 Life sciences; biology
610 Medicine & health
Language:English
Date:2018
Deposited On:12 Feb 2019 16:14
Last Modified:25 Sep 2019 00:25
Publisher:Springer
ISSN:2196-5471
OA Status:Closed
Publisher DOI:https://doi.org/10.1007/s40588-018-0089-7

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