Header

UZH-Logo

Maintenance Infos

Epicardial adipose tissue volume is associated with adverse outcomes after transcatheter aortic valve replacement


Eberhard, Matthias; Stocker, Daniel; Meyer, Martin; Kebernik, Julia; Stähli, Barbara E; Frauenfelder, Thomas; Maisano, Francesco; Ruschitzka, Frank; Nietlispach, Fabian; Nguyen-Kim, Thi D L; Tanner, Felix C (2019). Epicardial adipose tissue volume is associated with adverse outcomes after transcatheter aortic valve replacement. International Journal of Cardiology, 286:29-35.

Abstract

BACKGROUND Epicardial adipose tissue (EAT) is involved in inflammation and associated with cardiovascular risk factors. It is not known whether EAT affects outcome of patients undergoing transcatheter aortic valve replacement (TAVR).
METHODS 503 consecutive patients undergoing TAVR at our institution between May 2008 and November 2015 were enrolled in a prospective registry. Multi-detector computed tomography (CT) was used for EAT quantification. Outcome was assessed by 1-, 2-, and 3-year mortality and the early safety endpoint at 30 days according to the VARC-2 criteria.
RESULTS EAT volume was larger in males than females (p = 0.003), while EAT volume indexed to BSA was similar in both genders (p = 0.348). There was a weak correlation of EAT volume with body mass index (BMI; r = 0.24; p < 0.001) and body surface area (BSA; r = 0.26; p < 0.001). Patients with larger EAT volume had an increased all-cause 1-, 2-, and 3-year mortality after TAVR in Kaplan-Meier analyses using different binary cut-off values of 100 mm (log-rank p = 0.002; HR: 1.94, 95%CI: 1.15-3.26), 125 mm (log-rank p = 0.001; HR: 1.70, 95%CI: 1.06-2.68), and 130 mm (log-rank p = 0.001; HR: 1.69, 95%CI: 1.10-2.60). Similarly, a larger EAT volume indicated an increased risk to reach the early safety endpoint for cut-off values of 125 mm (OR: 1.82; 95%CI: 1.06-3.11; p = 0.029), and 130 mm (OR: 1.91; 95%CI: 1.13-3.23; p = 0.016). Indexing EAT volume did not strengthen correlation of EAT with outcome.
CONCLUSION EAT volume is independently associated with all-cause 1-, 2-, and 3-year mortality as well as the early safety endpoint in patients with severe aortic stenosis undergoing TAVR.

Abstract

BACKGROUND Epicardial adipose tissue (EAT) is involved in inflammation and associated with cardiovascular risk factors. It is not known whether EAT affects outcome of patients undergoing transcatheter aortic valve replacement (TAVR).
METHODS 503 consecutive patients undergoing TAVR at our institution between May 2008 and November 2015 were enrolled in a prospective registry. Multi-detector computed tomography (CT) was used for EAT quantification. Outcome was assessed by 1-, 2-, and 3-year mortality and the early safety endpoint at 30 days according to the VARC-2 criteria.
RESULTS EAT volume was larger in males than females (p = 0.003), while EAT volume indexed to BSA was similar in both genders (p = 0.348). There was a weak correlation of EAT volume with body mass index (BMI; r = 0.24; p < 0.001) and body surface area (BSA; r = 0.26; p < 0.001). Patients with larger EAT volume had an increased all-cause 1-, 2-, and 3-year mortality after TAVR in Kaplan-Meier analyses using different binary cut-off values of 100 mm (log-rank p = 0.002; HR: 1.94, 95%CI: 1.15-3.26), 125 mm (log-rank p = 0.001; HR: 1.70, 95%CI: 1.06-2.68), and 130 mm (log-rank p = 0.001; HR: 1.69, 95%CI: 1.10-2.60). Similarly, a larger EAT volume indicated an increased risk to reach the early safety endpoint for cut-off values of 125 mm (OR: 1.82; 95%CI: 1.06-3.11; p = 0.029), and 130 mm (OR: 1.91; 95%CI: 1.13-3.23; p = 0.016). Indexing EAT volume did not strengthen correlation of EAT with outcome.
CONCLUSION EAT volume is independently associated with all-cause 1-, 2-, and 3-year mortality as well as the early safety endpoint in patients with severe aortic stenosis undergoing TAVR.

Statistics

Citations

Dimensions.ai Metrics
1 citation in Web of Science®
2 citations in Scopus®
Google Scholar™

Altmetrics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Cardiovascular Surgery
04 Faculty of Medicine > University Hospital Zurich > Clinic for Diagnostic and Interventional Radiology
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:Aortic Stenosis Computed tomography Epicardial adipose tissue Transcatheter aortic valve replacement
Language:English
Date:1 July 2019
Deposited On:21 Feb 2019 15:29
Last Modified:25 Sep 2019 00:25
Publisher:Elsevier
ISSN:0167-5273
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.ijcard.2019.01.068
PubMed ID:30712847

Download

Full text not available from this repository.
View at publisher

Get full-text in a library