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Epigenetic mechanisms of tumor resistance to immunotherapy


Arenas-Ramirez, Natalia; Sahin, Dilara; Boyman, Onur (2018). Epigenetic mechanisms of tumor resistance to immunotherapy. Cellular and Molecular Life Sciences, 75(22):4163-4176.

Abstract

The recent impact of cancer immunotherapies has firmly established the ability and importance of the immune system to fight malignancies. However, the intimate interaction between the highly dynamic tumor and immune cells leads to a selection process driven by genetic and epigenetic processes. As the molecular pathways of cancer resistance mechanisms to immunotherapy become increasingly known, novel therapeutic targets are being tested in combination with immune-stimulating approaches. We here review recent insights into the molecular mechanisms of tumor resistance with particular emphasis on epigenetic processes and place these in the context of previous models.

Abstract

The recent impact of cancer immunotherapies has firmly established the ability and importance of the immune system to fight malignancies. However, the intimate interaction between the highly dynamic tumor and immune cells leads to a selection process driven by genetic and epigenetic processes. As the molecular pathways of cancer resistance mechanisms to immunotherapy become increasingly known, novel therapeutic targets are being tested in combination with immune-stimulating approaches. We here review recent insights into the molecular mechanisms of tumor resistance with particular emphasis on epigenetic processes and place these in the context of previous models.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Immunology
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:Molecular Medicine, Cell Biology, Molecular Biology, Pharmacology, Cellular and Molecular Neuroscience
Language:English
Date:1 November 2018
Deposited On:08 Mar 2019 08:38
Last Modified:08 Mar 2019 08:39
Publisher:Springer
ISSN:1420-682X
OA Status:Closed
Publisher DOI:https://doi.org/10.1007/s00018-018-2908-7
PubMed ID:30140960

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