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Association study of essential tremor genetic loci in Parkinson's disease


Ross, Jay P; Mohtashami, Sadaf; Leveille, Etienne; Johnson, Amelie M; Xiong, Lan; Dion, Patrick A; Fon, Edward; Dauvilliers, Yves; Dupré, Nicolas; Rouleau, Guy A; Gan-Or, Ziv (2018). Association study of essential tremor genetic loci in Parkinson's disease. Neurobiology of Aging, 66:178.e13-178.e15.

Abstract

A recent genome-wide association study identified variants associated with essential tremor (ET). The present study aimed to examine potential genetic overlap between ET and Parkinson's disease (PD). The top 22 variants identified by the ET genome-wide association study and 4 additional variants from previous studies were genotyped in a cohort of French and French-Canadian PD patients (n = 717) and controls (n = 595). Logistic regression analysis, adjusted for age and sex, was used to test for association between genotype and PD. None of the variants tested in the present study was significantly associated with PD. Our results do not support a role of ET-associated genetic variants in PD.

Abstract

A recent genome-wide association study identified variants associated with essential tremor (ET). The present study aimed to examine potential genetic overlap between ET and Parkinson's disease (PD). The top 22 variants identified by the ET genome-wide association study and 4 additional variants from previous studies were genotyped in a cohort of French and French-Canadian PD patients (n = 717) and controls (n = 595). Logistic regression analysis, adjusted for age and sex, was used to test for association between genotype and PD. None of the variants tested in the present study was significantly associated with PD. Our results do not support a role of ET-associated genetic variants in PD.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Vascular Surgery
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:June 2018
Deposited On:08 Mar 2019 08:26
Last Modified:25 Sep 2019 00:26
Publisher:Elsevier
ISSN:0197-4580
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.neurobiolaging.2018.01.001
PubMed ID:29398123

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