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Experimental infection of four horses with Ehrlichia phagocytophila


Pusterla, N; Lutz, H; Braun, Ueli (1998). Experimental infection of four horses with Ehrlichia phagocytophila. Veterinary Record, 143(11):303-305.

Abstract

Four clinically healthy horses which were negative for antibodies to Ehrlichia phagocytophila, the agent of bovine ehrlichiosis, were infected experimentally with E phagocytophila-containing bovine leucocytes, administered intravenously. The horses were examined daily for four weeks, and blood samples were collected daily for cytological, haematological and biochemical examination and for a nested polymerase chain reaction (PCR). An indirect immunofluorescence test was used to determine when the horses seroconverted and the duration of positive titres. There were no abnormal clinical, haematological or biochemical findings in any of the four horses and all the PCRs yielded negative results. However, all the horses seroconverted with reciprocal titres of up to 1280, and the positive titres persisted for up to five months.

Abstract

Four clinically healthy horses which were negative for antibodies to Ehrlichia phagocytophila, the agent of bovine ehrlichiosis, were infected experimentally with E phagocytophila-containing bovine leucocytes, administered intravenously. The horses were examined daily for four weeks, and blood samples were collected daily for cytological, haematological and biochemical examination and for a nested polymerase chain reaction (PCR). An indirect immunofluorescence test was used to determine when the horses seroconverted and the duration of positive titres. There were no abnormal clinical, haematological or biochemical findings in any of the four horses and all the PCRs yielded negative results. However, all the horses seroconverted with reciprocal titres of up to 1280, and the positive titres persisted for up to five months.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Veterinary Clinic > Department of Farm Animals
Dewey Decimal Classification:570 Life sciences; biology
630 Agriculture
Language:English
Date:12 September 1998
Deposited On:22 Feb 2019 16:03
Last Modified:24 Feb 2019 06:50
Publisher:BMJ Publishing Group
ISSN:0042-4900
OA Status:Closed
Publisher DOI:https://doi.org/10.1136/vr.143.11.303
PubMed ID:9789347

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