Halalopathic, the proposed concept, is based on the compatibility between therapy and individual’s belief where the “power of word, tranquility and therapeutic agents” work cooperatively to induce more effective treatment. The healing approach may well affect non-genetic changes that human genome experiences as a result of interaction with the environment. To realize the concept, ingredients and processes need to be evaluated with regards to Halal standard. Halala-Tayyiba label on medicine will reveal to the patient that drug has been prepared under maximum hygiene, minimum contamination and the whole process is clean, pure and comply with Islamic principle. Halalopathic generate compatible system which will reflect on the chemistry of our bodies where disorder is decreased, and ultimately lower the entropy and increase the overall potential energy. The concept promotes personalized therapy and open new window for more effective treatment.