PURPOSE To compare 5-year real-world outcomes of eyes with classic and occult choroidal neovascularization (CNV) treated with anti-Vascular Endothelial Growth Factor (anti-VEGF) injections.
DESIGN Retrospective analysis from a prospectively designed observational database.
METHODS Treatment-naïve eyes diagnosed with occult, minimally or predominantly classic CNV that commenced anti-VEGF treatment between Jan-2007 and Dec-2012 were identified from a registry of neovascular age related macular degeneration (nAMD) treatment outcomes. Baseline characteristics, visual acuity (VA) at 5 years, change in VA, time to first inactivation, number of injections and proportion of visits graded with active nAMD over the 5 years were compared between the 3 groups.
RESULTS 1929 eyes from 1730 subjects (1196 occult, 289 minimally classic and 444 predominantly classic CNV) were analysed. Baseline VA (mean[SD]) was higher in occult CNVs (56.9[17.4] letters) than in minimally (52.9[19.7] letters) and predominantly (49.1[19.9] letters) classic CNVs (p=0.003 and p<0.0001 respectively). VA change was similar across the groups. At 5 years eyes with occult CNVs still had better VA than other CNVs. Age, lesion size and baseline VA, but not CNV type, significantly affected final VA in the multivariate model. Predominantly classic CNVs became inactive sooner and were overall less active than other CNV types. The number of injections received was similar across the groups.
CONCLUSIONS Eyes with occult CNVs had overall a better VA than other CNVs. The difference in final VA was not significant after adjusting for baseline VA. Five-year outcomes and treatment patterns were not affected by the lesion type.