Eichenberger, Larissa S; Patra, Malay; Holland, Jason P (2019). Photoactive chelates for radiolabelling proteins. Chemical Communications, 55(16):2257-2260.
Photochemical reactions are an attractive foundation for the synthesis of radiolabelled antibodies, immunoglobulin fragments and other proteins/peptides. The synthesis, 68Ga-radiochemistry and photochemical reactivity of three macrocyclic chelates functionalised with an arylazide group is described. Experiments with trastuzumab confirmed that photoradiochemistry facilitates fast, one-pot synthesis of radiolabelled proteins.
Photochemical reactions are an attractive foundation for the synthesis of radiolabelled antibodies, immunoglobulin fragments and other proteins/peptides. The synthesis, 68Ga-radiochemistry and photochemical reactivity of three macrocyclic chelates functionalised with an arylazide group is described. Experiments with trastuzumab confirmed that photoradiochemistry facilitates fast, one-pot synthesis of radiolabelled proteins.
| Item Type: | Journal Article, refereed, further contribution |
|---|---|
| Communities & Collections: | 07 Faculty of Science > Department of Chemistry |
| Dewey Decimal Classification: | 540 Chemistry |
| Scopus Subject Areas: | Physical Sciences > Catalysis
Physical Sciences > Electronic, Optical and Magnetic Materials Physical Sciences > Ceramics and Composites Physical Sciences > General Chemistry Physical Sciences > Surfaces, Coatings and Films Physical Sciences > Metals and Alloys Physical Sciences > Materials Chemistry |
| Uncontrolled Keywords: | Materials Chemistry, Electronic, Optical and Magnetic Materials, General Chemistry, Surfaces, Coatings and Films, Metals and Alloys, Ceramics and Composites, Catalysis |
| Language: | English |
| Date: | 1 January 2019 |
| Deposited On: | 24 Apr 2019 13:54 |
| Last Modified: | 26 Jan 2022 21:40 |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 1359-7345 |
| OA Status: | Green |
| Publisher DOI: | https://doi.org/10.1039/c8cc09660k |
| Project Information: |
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Eichenberger, Larissa S