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Gene and miRNA expression in giant cell arteritis-a concise systematic review of significantly modified studies


Kuret, Tadeja; Burja, Blaž; Feichtinger, Julia; Thallinger, Gerhard G; Frank-Bertoncelj, Mojca; Lakota, Katja; Žigon, Polona; Sodin-Semrl, Snezna; Čučnik, Saša; Tomšič, Matija; Hočevar, Alojzija (2019). Gene and miRNA expression in giant cell arteritis-a concise systematic review of significantly modified studies. Clinical Rheumatology, 38(2):307-316.

Abstract

Giant cell arteritis (GCA) is a systemic vasculitis in individuals older than 50 years, characterized by headaches, visual disturbances, painful scalp, jaw claudication, impairment of limb arteries, and systemic inflammation, among other symptoms. GCA diagnosis is confirmed by a positive temporal artery biopsy (TAB) or by imaging modalities. A prominent acute phase response with inflammation is the hallmark of the disease, predominantly targeting large- and medium-sized arteries leading to stenosis or occlusion of arterial lumen. To date, there are no reliable tissue markers specific for GCA. Scarce reports have indicated the importance of epigenetics in GCA. The current systematic review reports significantly changed candidate biomarkers in TABs of GCA patients compared to non-GCA patients using qPCR.

Abstract

Giant cell arteritis (GCA) is a systemic vasculitis in individuals older than 50 years, characterized by headaches, visual disturbances, painful scalp, jaw claudication, impairment of limb arteries, and systemic inflammation, among other symptoms. GCA diagnosis is confirmed by a positive temporal artery biopsy (TAB) or by imaging modalities. A prominent acute phase response with inflammation is the hallmark of the disease, predominantly targeting large- and medium-sized arteries leading to stenosis or occlusion of arterial lumen. To date, there are no reliable tissue markers specific for GCA. Scarce reports have indicated the importance of epigenetics in GCA. The current systematic review reports significantly changed candidate biomarkers in TABs of GCA patients compared to non-GCA patients using qPCR.

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Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Rheumatology Clinic and Institute of Physical Medicine
Dewey Decimal Classification:610 Medicine & health
Language:English
Date:February 2019
Deposited On:21 May 2019 12:48
Last Modified:25 Sep 2019 00:34
Publisher:Springer
ISSN:0770-3198
OA Status:Closed
Publisher DOI:https://doi.org/10.1007/s10067-018-4231-y
PubMed ID:30069799

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