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The impact of inhaled bronchodilators on bronchopulmonary dysplasia: a nonrandomized comparison from the NEuroSIS trial


Koch, Alexander; Kreutzer, Karen B; Poets, Christian; Engel, Corinna; Bassler, Dirk; NEuroSIS Trial Group (2020). The impact of inhaled bronchodilators on bronchopulmonary dysplasia: a nonrandomized comparison from the NEuroSIS trial. Journal of Maternal-Fetal & Neonatal Medicine, 33(23):4030-4032.

Abstract

BACKGROUND Inhaled bronchodilators improve pulmonary function. Their effects on bronchopulmonary dysplasia (BPD) are uncertain. We assessed the efficacy of early inhaled bronchodilators on the risk of BPD and death in extremely preterm infants.
METHODS We performed a post-hoc analysis of prospectively collected data from the Neonatal European Study of Inhaled Steroids (NEuroSIS). In NEuroSIS, 863 extremely preterm infants were randomly assigned to receive early inhaled budesonide or placebo. We now performed nonrandomized comparisons between infants that participated in the NEUROSIS trial and either received early (within the first 48 h of life) bronchodilators or no bronchodilators. Groups were assembled according to predefined criteria stated in the study protocol and we used the same prespecified primary outcome as in the main study, a composite of BPD and death at a postmenstrual age of 36 weeks.
RESULTS Treatment groups did not differ significantly in the composite outcome of BPD and death at 36 weeks postmenstrual age: bronchodilator group (20/46; 43.5%), versus 349/810 (43.1%) in the no bronchodilator group; (p = .97). Analyzed by individual components, there were no significant differences in BPD and death rates between the groups.
DISCUSSION Based on our analyses, early inhaled bronchodilators did not reduce the risk of BPD and death in extremely preterm infants.

Abstract

BACKGROUND Inhaled bronchodilators improve pulmonary function. Their effects on bronchopulmonary dysplasia (BPD) are uncertain. We assessed the efficacy of early inhaled bronchodilators on the risk of BPD and death in extremely preterm infants.
METHODS We performed a post-hoc analysis of prospectively collected data from the Neonatal European Study of Inhaled Steroids (NEuroSIS). In NEuroSIS, 863 extremely preterm infants were randomly assigned to receive early inhaled budesonide or placebo. We now performed nonrandomized comparisons between infants that participated in the NEUROSIS trial and either received early (within the first 48 h of life) bronchodilators or no bronchodilators. Groups were assembled according to predefined criteria stated in the study protocol and we used the same prespecified primary outcome as in the main study, a composite of BPD and death at a postmenstrual age of 36 weeks.
RESULTS Treatment groups did not differ significantly in the composite outcome of BPD and death at 36 weeks postmenstrual age: bronchodilator group (20/46; 43.5%), versus 349/810 (43.1%) in the no bronchodilator group; (p = .97). Analyzed by individual components, there were no significant differences in BPD and death rates between the groups.
DISCUSSION Based on our analyses, early inhaled bronchodilators did not reduce the risk of BPD and death in extremely preterm infants.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neonatology
Dewey Decimal Classification:610 Medicine & health
Scopus Subject Areas:Health Sciences > Pediatrics, Perinatology and Child Health
Health Sciences > Obstetrics and Gynecology
Language:English
Date:1 December 2020
Deposited On:24 May 2019 12:57
Last Modified:10 Oct 2020 01:01
Publisher:Informa Healthcare
ISSN:1476-4954
OA Status:Closed
Publisher DOI:https://doi.org/10.1080/14767058.2019.1590331
PubMed ID:30922128

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