Header

UZH-Logo

Maintenance Infos

Absorption spectra of early stool from preterm infants need to be considered in abdominal NIRS oximetry


Isler, Helene; Schenk, Daniel; Bernhard, Jérôme; Kleiser, Stefan; Scholkmann, Felix; Ostojic, Daniel; Kalyanov, Alexander; Ahnen, Linda; Wolf, Martin; Karen, Tanja (2019). Absorption spectra of early stool from preterm infants need to be considered in abdominal NIRS oximetry. Biomedical Optics Express, 10(6):2784-2794.

Abstract

Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency of the preterm infant. Low abdominal tissue oxygen saturation (StO2) measured by near-infrared spectroscopy (NIRS) oximetry may be an early sign of NEC relevant for treating or even preventing NEC. However, current commercial NIRS oximeters provide inaccurate StO2 readings because they neglect stool as an abdominal absorber. To tackle this problem, we determined the optical properties of faeces of preterm infants to enable a correct abdominal StO2 measurement. In 25 preterm born infants (median age 31 0/7 ± 2 1/7 weeks, weight 1478 ± 511 g), we measured their first five stool probes with a VIS/NIR spectrometer and calculated the optical properties using the Inverse Adding Doubling (IAD) method. We obtained two absorption spectra representing meconium and transitional stool. Probabilistic cluster analysis correctly classified 96 out of 107 stool probes. The faeces spectra need to be considered to enable correct abdominal StO2 measurements with NIRS oximetry.

Abstract

Necrotizing enterocolitis (NEC) is the most common gastrointestinal emergency of the preterm infant. Low abdominal tissue oxygen saturation (StO2) measured by near-infrared spectroscopy (NIRS) oximetry may be an early sign of NEC relevant for treating or even preventing NEC. However, current commercial NIRS oximeters provide inaccurate StO2 readings because they neglect stool as an abdominal absorber. To tackle this problem, we determined the optical properties of faeces of preterm infants to enable a correct abdominal StO2 measurement. In 25 preterm born infants (median age 31 0/7 ± 2 1/7 weeks, weight 1478 ± 511 g), we measured their first five stool probes with a VIS/NIR spectrometer and calculated the optical properties using the Inverse Adding Doubling (IAD) method. We obtained two absorption spectra representing meconium and transitional stool. Probabilistic cluster analysis correctly classified 96 out of 107 stool probes. The faeces spectra need to be considered to enable correct abdominal StO2 measurements with NIRS oximetry.

Statistics

Citations

Altmetrics

Downloads

15 downloads since deposited on 24 May 2019
15 downloads since 12 months
Detailed statistics

Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Clinic for Neonatology
Dewey Decimal Classification:610 Medicine & health
Uncontrolled Keywords:Biotechnology, Atomic and Molecular Physics, and Optics
Language:English
Date:1 June 2019
Deposited On:24 May 2019 13:09
Last Modified:25 Sep 2019 00:35
Publisher:Optical Society of America
ISSN:2156-7085
OA Status:Gold
Free access at:PubMed ID. An embargo period may apply.
Publisher DOI:https://doi.org/10.1364/boe.10.002784
PubMed ID:31259051
Project Information:
  • : FunderSNSF
  • : Grant ID320030_159490
  • : Project TitleBeyond individual brain activity: Assessing inter-personal brain coupling using functional near-infrared imaging (fNIRI) hyperscanning

Download

Download PDF  'Absorption spectra of early stool from preterm infants need to be considered in abdominal NIRS oximetry'.
Preview
Content: Published Version
Filetype: PDF
Size: 3MB
View at publisher