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Immunity to fungi


LeibundGut-Landmann, Salomé; Wüthrich, Marcel; Hohl, Tobias M (2012). Immunity to fungi. Current Opinion in Immunology, 24(4):449-458.

Abstract

The global increase in fungal disease burden, the emergence of novel pathogenic fungi, and the lack of fungal vaccines have focused intense interest in elucidating immune defense mechanisms against fungi. Recent studies in animal models and in humans identify an integrated role for C-type lectin and Toll-like receptor signaling in activating innate and adaptive responses that control medically relevant fungi. Beyond the critical role of phagocytes in host defense, the generation and balance of specific T helper subsets contributes to sterilizing immunity. These advances form a basis for the development of fungal vaccines and immune-based therapeutic adjuncts.

Abstract

The global increase in fungal disease burden, the emergence of novel pathogenic fungi, and the lack of fungal vaccines have focused intense interest in elucidating immune defense mechanisms against fungi. Recent studies in animal models and in humans identify an integrated role for C-type lectin and Toll-like receptor signaling in activating innate and adaptive responses that control medically relevant fungi. Beyond the critical role of phagocytes in host defense, the generation and balance of specific T helper subsets contributes to sterilizing immunity. These advances form a basis for the development of fungal vaccines and immune-based therapeutic adjuncts.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Virology
Dewey Decimal Classification:570 Life sciences; biology
Scopus Subject Areas:Health Sciences > Immunology and Allergy
Life Sciences > Immunology
Uncontrolled Keywords:Immunology, Immunology and Allergy
Language:English
Date:1 August 2012
Deposited On:04 Jul 2019 12:01
Last Modified:31 Jul 2020 03:27
Publisher:Elsevier
ISSN:0952-7915
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.coi.2012.04.007
PubMed ID:22613091
Project Information:
  • : FunderSNSF
  • : Grant IDPP00P3_123342
  • : Project TitleHost defense against fungal infections

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