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Myeloid C-type lectins in innate immunity


Robinson, Matthew J; Sancho, David; Slack, Emma C; LeibundGut-Landmann, Salomé; Sousa, Caetano Reis e (2006). Myeloid C-type lectins in innate immunity. Nature Immunology, 7(12):1258-1265.

Abstract

C-type lectins expressed on myeloid cells comprise a family of proteins that share a common structural motif, and some act as receptors in pathogen recognition. But just as the presence of leucine-rich repeats alone is not sufficient to define a Toll-like receptor, the characterization of C-type lectin receptors in innate immunity requires the identification of accompanying signaling motifs. Here we focus on the known signaling pathways of myeloid C-type lectins and on their possible functions as autonomous activating or inhibitory receptors involved in innate responses to pathogens or self.

Abstract

C-type lectins expressed on myeloid cells comprise a family of proteins that share a common structural motif, and some act as receptors in pathogen recognition. But just as the presence of leucine-rich repeats alone is not sufficient to define a Toll-like receptor, the characterization of C-type lectin receptors in innate immunity requires the identification of accompanying signaling motifs. Here we focus on the known signaling pathways of myeloid C-type lectins and on their possible functions as autonomous activating or inhibitory receptors involved in innate responses to pathogens or self.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Virology
Dewey Decimal Classification:570 Life sciences; biology
Scopus Subject Areas:Health Sciences > Immunology and Allergy
Life Sciences > Immunology
Uncontrolled Keywords:Immunology
Language:English
Date:1 December 2006
Deposited On:04 Jul 2019 12:03
Last Modified:21 Jan 2022 14:49
Publisher:Nature Publishing Group
ISSN:1529-2908
OA Status:Closed
Publisher DOI:https://doi.org/10.1038/ni1417
PubMed ID:17110942