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Regulation of MHC class II gene expression by the class II transactivator


Reith, Walter; LeibundGut-Landmann, Salomé; Waldburger, Jean-Marc (2005). Regulation of MHC class II gene expression by the class II transactivator. Nature Reviews. Immunology, 5(10):793-806.

Abstract

MHC class II molecules are pivotal for the adaptive immune system, because they guide the development and activation of CD4+ T helper cells. Fulfilling these functions requires that the genes encoding MHC class II molecules are transcribed according to a strict cell-type-specific and quantitatively modulated pattern. This complex gene-expression profile is controlled almost exclusively by a single master regulatory factor, which is known as the class II transactivator. As we discuss here, differential activation of the three independent promoters that drive expression of the gene encoding the class II transactivator ultimately determines the exquisitely regulated pattern of MHC class II gene expression.

Abstract

MHC class II molecules are pivotal for the adaptive immune system, because they guide the development and activation of CD4+ T helper cells. Fulfilling these functions requires that the genes encoding MHC class II molecules are transcribed according to a strict cell-type-specific and quantitatively modulated pattern. This complex gene-expression profile is controlled almost exclusively by a single master regulatory factor, which is known as the class II transactivator. As we discuss here, differential activation of the three independent promoters that drive expression of the gene encoding the class II transactivator ultimately determines the exquisitely regulated pattern of MHC class II gene expression.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:05 Vetsuisse Faculty > Institute of Virology
Dewey Decimal Classification:570 Life sciences; biology
Scopus Subject Areas:Health Sciences > Immunology and Allergy
Life Sciences > Immunology
Uncontrolled Keywords:Immunology
Language:English
Date:1 October 2005
Deposited On:04 Jul 2019 12:04
Last Modified:31 Jul 2020 03:27
Publisher:Nature Publishing Group
ISSN:1474-1733
OA Status:Closed
Publisher DOI:https://doi.org/10.1038/nri1708
PubMed ID:16200082

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