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1-Deoxysphingolipids


Lone, M A; Santos, T; Alecu, I; Silva, L C; Hornemann, T (2019). 1-Deoxysphingolipids. Biochimica and Biophysica Acta. Molecular and Cell Biology of Lipids, 1864(4):512-521.

Abstract

Sphingolipids (SLs) are fundamental components of eukaryotic cells. 1-Deoxysphingolipids differ structurally from canonical SLs as they lack the essential C1-OH group. Consequently, 1-deoxysphingolipids cannot be converted to complex sphingolipids and are not degraded over the canonical catabolic pathways. Pathologically elevated 1-deoxySLs are involved in several disease conditions. Within this review, we will provide an up-to-date overview on the metabolic, physiological and pathophysiological aspects of this enigmatic class of "headless" sphingolipids.

Abstract

Sphingolipids (SLs) are fundamental components of eukaryotic cells. 1-Deoxysphingolipids differ structurally from canonical SLs as they lack the essential C1-OH group. Consequently, 1-deoxysphingolipids cannot be converted to complex sphingolipids and are not degraded over the canonical catabolic pathways. Pathologically elevated 1-deoxySLs are involved in several disease conditions. Within this review, we will provide an up-to-date overview on the metabolic, physiological and pathophysiological aspects of this enigmatic class of "headless" sphingolipids.

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Additional indexing

Item Type:Journal Article, refereed, further contribution
Communities & Collections:04 Faculty of Medicine > University Hospital Zurich > Institute of Clinical Chemistry
Dewey Decimal Classification:610 Medicine & health
540 Chemistry
Language:English
Date:April 2019
Deposited On:02 Jul 2019 15:12
Last Modified:25 Sep 2019 00:37
Publisher:Elsevier
ISSN:1388-1981
OA Status:Closed
Publisher DOI:https://doi.org/10.1016/j.bbalip.2018.12.013
PubMed ID:30625374

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