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Establishing intra- and inter-vendor reproducibility of T1 relaxation time measurements with 3T MRI


Lee, Yoojin; Callaghan, Martina F; Acosta-Cabronero, Julio; Lutti, Antoine; Nagy, Zoltan (2019). Establishing intra- and inter-vendor reproducibility of T1 relaxation time measurements with 3T MRI. Magnetic Resonance in Medicine, 81(1):454-465.

Abstract

PURPOSE: Parametric imaging methods (e.g., T1 relaxation time mapping) have been shown to be more reproducible across time and vendors than weighted (e.g., T1-weighted) images. The purpose of this work was to more extensively evaluate the validity of this assertion.
METHODS: Seven volunteers underwent twice-repeated acquisitions of variable flip-angle T1 mapping, including B1 + calibration, on a 3T Philips Achieva and 3T Siemens Trio scanner. Intra-scanner and inter-vendor T1 variability were calculated. To determine T1 reproducibility levels in longitudinal settings, or after changing hardware or software, four additional data sets were acquired from two of the participants; one participant was scanned on a different 3T Siemens Trio scanner and another on the same 3T Philips Achieva scanner but after a software upgrade.
RESULTS: Intra-scanner variability of voxel-wise T1 values was consistent between the two vendors, averaging 0.7/0.7/1.3/1.4% in white matter/cortical gray matter/subcortical gray matter/cerebellum, respectively. We observed, however, a systematic bias between the two vendors of https://doi.org/10.0/7.8/8.6/10.0%, respectively. The T1 bias across two scanners of the same model was greater than intra-scanner variability, although still only at 1.4/1.0/1.9/2.3%, respectively. A greater bias was identified for data sets acquired before/after software upgrade in white matter/cortical gray matter (3.6/2.7%) whereas variability in subcortical gray matter/cerebellum was comparable (1.7/1.9%).
CONCLUSION: We established intra- and inter-vendor reproducibility levels for a widely used T1 mapping protocol. We anticipate that these results will guide the design of multi-center studies, particularly those encompassing multiple vendors. Furthermore, this baseline level of reproducibility should be established or surpassed during the piloting phase of such studies.

Abstract

PURPOSE: Parametric imaging methods (e.g., T1 relaxation time mapping) have been shown to be more reproducible across time and vendors than weighted (e.g., T1-weighted) images. The purpose of this work was to more extensively evaluate the validity of this assertion.
METHODS: Seven volunteers underwent twice-repeated acquisitions of variable flip-angle T1 mapping, including B1 + calibration, on a 3T Philips Achieva and 3T Siemens Trio scanner. Intra-scanner and inter-vendor T1 variability were calculated. To determine T1 reproducibility levels in longitudinal settings, or after changing hardware or software, four additional data sets were acquired from two of the participants; one participant was scanned on a different 3T Siemens Trio scanner and another on the same 3T Philips Achieva scanner but after a software upgrade.
RESULTS: Intra-scanner variability of voxel-wise T1 values was consistent between the two vendors, averaging 0.7/0.7/1.3/1.4% in white matter/cortical gray matter/subcortical gray matter/cerebellum, respectively. We observed, however, a systematic bias between the two vendors of https://doi.org/10.0/7.8/8.6/10.0%, respectively. The T1 bias across two scanners of the same model was greater than intra-scanner variability, although still only at 1.4/1.0/1.9/2.3%, respectively. A greater bias was identified for data sets acquired before/after software upgrade in white matter/cortical gray matter (3.6/2.7%) whereas variability in subcortical gray matter/cerebellum was comparable (1.7/1.9%).
CONCLUSION: We established intra- and inter-vendor reproducibility levels for a widely used T1 mapping protocol. We anticipate that these results will guide the design of multi-center studies, particularly those encompassing multiple vendors. Furthermore, this baseline level of reproducibility should be established or surpassed during the piloting phase of such studies.

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Additional indexing

Item Type:Journal Article, refereed, original work
Communities & Collections:03 Faculty of Economics > Department of Economics
Dewey Decimal Classification:330 Economics
Scopus Subject Areas:Health Sciences > Radiology, Nuclear Medicine and Imaging
Uncontrolled Keywords:Radiology Nuclear Medicine and imaging, 3T, bias, multi‐vendor, parametric imaging, reproducibility, T1 relaxation
Language:English
Date:January 2019
Deposited On:10 Jul 2019 14:49
Last Modified:01 Feb 2021 01:02
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:0740-3194
Additional Information:Accepted manuscript: This is the peer reviewed version of the following article: "Lee, Yoojin; Callaghan, Martina F; Acosta-Cabronero, Julio; Lutti, Antoine; Nagy, Zoltan (2019). Establishing intra- and inter-vendor reproducibility of T1 relaxation time measurements with 3T MRI. Magnetic Resonance in Medicine, 81(1):454-465", which has been published in final form at https://doi.org/10.1002/mrm.27421. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. (http://www.wileyauthors.com/self-archiving)
OA Status:Green
Publisher DOI:https://doi.org/10.1002/mrm.27421
Project Information:
  • : FunderSNSF
  • : Grant ID31003A_166118
  • : Project TitleAdvanced non-invasive human in-vivo cortical parcellation using multimodal MRI

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