Understanding how animal behavior can influence the susceptibility of endangered hosts to emerging pathogens and using this knowledge to ameliorate negative effects of infectious wildlife diseases is a promising avenue in conservation biology. Chytridiomycosis, an emerging infectious disease caused by the fungal pathogen Batrachochytrium dendrobatidis (Bd) in amphibians has led to the most spectacular disease-borne loss of vertebrate biodiversity ever recorded in history. Unfortunately, the methods of mitigation that are available today are only practical in captive populations, and an effective method that could be applied in natural habitats without inflicting vast collateral damage is lacking. We suggest here that the thermal tolerance mismatch between Bd and its ectothermic hosts coupled with the thermoregulatory behavior of amphibians could be exploited in mitigation interventions combating Bd infection in situ. If microhabitats with elevated temperatures are made available in their natural environment, individuals taking advantage of the possibility to reach their preferred body temperature could critically lower their infection intensity or even clear the pathogen. We provide a basis for studying this approach by reviewing the evidence that supports the idea, describing how technical difficulties may be overcome, pointing out gaps in our knowledge that need to be filled by future studies, and listing presumable benefits and probable limitations of localized heating. The proposed approach has good potential to become an effective in situ mitigation method that can be easily employed in a wide taxonomic range of amphibians, especially in species that are warm-adapted, while causing less collateral damage than any other method that is currently available. If so, it may quickly become a widely applicable tool of biodiversity conservation and may contribute to saving many amphibian populations and species from extinction in the next few decades.